Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract
| Autor: | SILVA, D. T. da, SMANIOTTO, F. A., COSTA, I. F., BARANZELLI, J., MULLER, A., SOMACAL, S., MONTEIRO, C. S., VIZZOTTO, M., RODRIGUES, E., BARCIA, M. T., EMANUELLI, T. |
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| Přispěvatelé: | DARIANE TRIVISIOL DA SILVA, FRANCIELE ALINE SMANIOTTO, ISABELLA FERREIRA COSTA, JULIA BARANZELLI, ALINE MULLER, SABRINA SOMACAL, CAMILA SANT'ANNA MONTEIRO, MARCIA VIZZOTTO, CPACT, ELISEU RODRIGUES, MILENE TEIXEIRA BARCIA, TATIANA EMANUELLI. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice) Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA |
| Popis: | This study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds. SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS analysis of blood and cecal feces. Non-compartmental pharmacokinetic analysis revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochemicals, choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins. Made available in DSpace on 2021-12-17T23:47:31Z (GMT). No. of bitstreams: 1 Artigo-Natural-deep-eutectic-solvent.pdf: 1392118 bytes, checksum: 389a9fad95dfa6e053fd249815318853 (MD5) Previous issue date: 2021 |
| Databáze: | OpenAIRE |
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