Reduction of salivary arginine catabolic activity through periodontal therapy

Autor: Pereira, Alexandre L., Cortelli, Sheila Cavalca, Aquino, Davi Romeiro, Franco, Gilson C. N., Cogo, Karina, Rodrigues, Edson, Costa, Fernando de Oliveira, Holzhausen, Marinella, Cortelli, José Roberto
Přispěvatelé: Rodrigues, Edson https://orcid.org/0000-0003-3968-6882, Muller, Karina Cogo https://orcid.org/0000-0002-9048-8702, Holzhausen, Marinella https://orcid.org/0000-0001-9413-5253, Costa, Fernando https://orcid.org/0000-0002-7687-1238, Rodrigues, Edson/C-6792-2015, Holzhausen, Marinella/G-2886-2012, Pereira, Alexandre/C-4227-2016, Muller, Karina Cogo/H-2365-2012, Holzhausen, Marinella/J-4298-2014
Rok vydání: 2012
Předmět:
Zdroj: Web of Science
Repositório Institucional da UNITAU
Universidade de Taubaté (UNITAU)
instacron:UNITAU
Popis: Made available in DSpace on 2019-09-12T16:57:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2012 Objective: Salivary enzymes may be used to diagnose periodontal conditions. Salivary arginase activity (SAA) is related to susceptibility to bacterial infection. Therefore, the aim of this controlled interventional study was to determine the SAA before and after non-surgical periodontal therapy. Method and Materials: Eighty-nine subjects were selected: 31 periodontally healthy patients (controls), 27 gingivitis patients, and 31 chronic periodontitis patients. Plaque and Gingival Indices, probing depth, and clinical attachment level were monitored. The presence of Campylobacter rectus, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Prevotella intermedia was evaluated by polymerase chain reaction. Salivary total protein level and SAA were also established by spectophotometry. Clinical and arginase data were analyzed using the Wilcoxon, Mann-Withney, and Kruskal-Wallis tests (P < .05). For microbial data, the chi-square test was used. The Pearson correlation test was also used between each parameter evaluated. Results: After therapy, due to a significant reduction in SAA, the values observed for the gingivitis and periodontitis groups were similar to those found in the healthy group. Interestingly, after therapy, SAA followed the same positive pattern showed by the overall improvement of clinical parameter (gingivitis and periodontitis group mean values, pre- > posttherapy) and by the reduction of target pathogens (gingivitis group T forsythia, pre- > posttherapy). Conclusion: Based on the reduction of SAA after therapy, in accordance with the expected reduction in clinical and microbiologic parameters, it was concluded that SAA has potential to serve as a reliable method to access to the therapeutic response of chronic periodontitis subjects treated with nonsurgical periodontal therapy. (Quintessence Int 2012;43:777-787) [Pereira, Alexandre L.; Cortelli, Sheila C.; Aquino, Davi R.; Franco, Gilson C. N.; Cogo, Karina; Cortelli, Jose R.] Universidade de Taubaté (Unitau), Dept Periodontol [Rodrigues, Edson] Universidade de Taubaté (Unitau), Dept Biol [Costa, Fernando O.] Univ Fed Minas Gerais, Dept Periodontol, Belo Horizonte, MG, Brazil [Holzhausen, Marinella] Univ Sao Paulo, Sch Dent, Dept Stomatol, Div Periodont, Sao Paulo, Brazil
Databáze: OpenAIRE
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