Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context

Autor: Zancheta, Roberta [UNESP], Possi, Ana P. M. [UNESP], Planeta, Cleopatra da Silva [UNESP], Marin, Marcelo Tadeu [UNESP]
Přispěvatelé: Universidade Estadual Paulista (Unesp), Universidade Federal de Uberlândia (UFU)
Jazyk: angličtina
Rok vydání: 2012
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Zdroj: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2013-08-12T18:17:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-01-01 Made available in DSpace on 2013-09-30T18:07:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:25:34Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T13:25:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Caffeine is the psychostimulant substance consumed in greatest quantities in the world. The repeated administration of psychostimulants can either decrease or increase the drug effect, inducing tolerance or sensitization, respectively, depending on administration procedure. Not only the dose and regimen, but also the environment where drug is administered, seem to modulate the changes in locomotor activity following repeated psychostimulant administration. The purpose of the present study was to examine the influence of the environmental context on caffeine-induced psychomotor stimulation following repeated administration of this drug. Our results showed that repeated caffeine induced psychomotor sensitization when drug injections were paired with the environment in which the animals were subsequently tested, whereas tolerance occurred when the animals received repeated caffeine in an environment different from that where the tests were performed. In conclusion, the present results demonstrated that the environmental context where caffeine is administered is a key factor modulating the adaptations of the organism to drug effects. Univ Estadual Paulista UNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil UFSCar UNESP, Interinst Grad Program Physiol Sci, BR-13565905 São Carlos, SP, Brazil Fed Univ Uberlandia UFU, Inst Biomed Sci, BR-38400902 Uberlandia, MG, Brazil Univ Estadual Paulista UNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP, Brazil UFSCar UNESP, Interinst Grad Program Physiol Sci, BR-13565905 São Carlos, SP, Brazil FAPESP: 07/57542-9 FAPESP: 07/57541-2 FAPESP: 08/10892 FAPESP: 08/01744-5
Databáze: OpenAIRE
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