Autonomic imbalance and metabolic changes in obese adolescents. Doctoral thesis

Autor: Hussid, Maria Fernanda
Přispěvatelé: Trombetta, Ivani Credidio, Fonseca, Felipe Xerez Cepêda, Consolim-Colombo, Fernanda Marciano, Dalboni, Maria Aparecida, Oliveira, Adriana Sarmento de
Jazyk: portugalština
Rok vydání: 2020
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações da Uninove
Universidade Nove de Julho (UNINOVE)
instacron:UNINOVE
Popis: Submitted by Nadir Basilio (nadirsb@uninove.br) on 2021-11-18T14:36:52Z No. of bitstreams: 1 Maria Fernanda Hussid.pdf: 3023100 bytes, checksum: 28fe9216ef8e01ca56f95bbcb6c64d72 (MD5) Made available in DSpace on 2021-11-18T14:36:52Z (GMT). No. of bitstreams: 1 Maria Fernanda Hussid.pdf: 3023100 bytes, checksum: 28fe9216ef8e01ca56f95bbcb6c64d72 (MD5) Previous issue date: 2020-08-28 INTRODUCTION: The prevalence of obesity in childhood and adolescence reached a pandemic level, leading to an increase in Metabolic Syndrome (MetS), arterial hypertension (AH) and obstructive sleep apnea (OSA). Obesity, OSA and AH independently share the same pathophysiological factors, including endothelial dysfunction, sympathetic hyperactivation and decreased baroreflex sensitivity. In a previous study, we observed that obese adolescents have endothelial dysfunction, having as predictor variables of decreased flow-mediated dilation (FMD), waist circumference (WC) and systolic blood pressure (SBP). It is not known whether, in addition to endothelial dysfunction, autonomic changes would be involved in the increase in BP in obese adolescents. OBJECTIVES: To analyze the autonomic mechanisms involved in the increase in blood pressure in obese adolescents, and the associated risk factors. METHODS: 25 Obese adolescents of both sexes and 14 Eutrophic adolescents (13.5 [13.0 - 15.8] and 14 [14 - 15.5] years old, respectively; P = 0.055), paired by sex, pubertal staging and height. Anthropometric data, body composition, risk factors for MetS (International Diabetes Federation), functional capacity assessed by the cardiopulmonary exercise test (VO2 peak), vascular function by FMD and OSA through the apnea-hypopnea index (AHI) and of minimum oxygen saturation (Min O2 Sat) on polysomnography were studied. Spectral analysis method was used for non-invasive assessment of the autonomic nervous system. The BP and HR signals were recorded using Finometer® and electrocardiogram, respectively, obtaining a tachogram and a sistogram using Windaq® software. Subsequently, such data were analyzed by Cardioseries® software, being evaluated R-R interval (time domain) and the predetermined frequency bands: low frequency (LF; sympathetic activity) between 0.04 and 0.15 Hz and high frequency (HF; parasympathetic activity) between 0.15 and 0.4 Hz. Relation LF / HF was calculated for the assessment of sympathetic-vagal balance. Baroreflex was calculated using the square root of the ratio between absolute LF (FC) / absolute LF (PAS). RESULTS: Obese adolescents presented increased weight values (100 ± 19.3 vs. 55 ± 8.0 kg; P
Databáze: OpenAIRE
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