Avaliação da interação entre trauma na infância e a variante rs110402 no gene do CRHR1 com o transtorno depressivo

Autor: Duarte, Malu Ribeiro
Přispěvatelé: Ghisleni, Gabriele Cordenonzi, Bastos, Clarissa Ribeiro, Trettin, Jessica Puchalski
Jazyk: portugalština
Rok vydání: 2021
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações do UCpel
Universidade Católica de Pelotas (UCPEL)
instacron:UCPEL
Popis: Submitted by Cristiane Chim (cristiane.chim@ucpel.edu.br) on 2022-07-22T12:24:51Z No. of bitstreams: 1 maluCaptura de tela 2022-07-22 091531.png: 41147 bytes, checksum: 010400fb6480ac3de5402a5fc7277fc9 (MD5) Made available in DSpace on 2022-07-22T12:24:52Z (GMT). No. of bitstreams: 1 maluCaptura de tela 2022-07-22 091531.png: 41147 bytes, checksum: 010400fb6480ac3de5402a5fc7277fc9 (MD5) Previous issue date: 2021-11-30 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES Introduction: Depressive disorder (DD) is considered a serious public health problem, multidimensional, and resulting from numerous social, psychological, and biological factors. Childhood trauma, ameliorated by harmful experiences and/or the absence of a reliable supportive and affectionate environment, has been associated with an increased vulnerability to stress-related psychiatric disorders, and with distinct changes in hypothalamic pituitary adrenal axis (HPA) function. In this context, genetic variants in the gene encoding the type 1 corticotrophin-releasing hormone receptor (CRHR1), as well as their interaction with stressful events, can moderate the body's sensitivity to specific environmental events. Objective: To investigate the effect of the rs110402 polymorphism in the CRHR1 gene on susceptibility to depressive disorder and to verify whether this effect is moderated by childhood trauma. Methods: This is a cross-sectional population-based study, carried out in the urban area of the city of Pelotas/RS, with a sample of 1126 adults aged 18 to 35 years old. Sample characteristics were assessed by a standard sociodemographic questionnaire, the diagnosis of past and current depressive episodes was made using the MINI 5.0 diagnostic interview, and the Childhood Trauma Questionnaire (CTQ) was used to assess the presence of childhood trauma. Total DNA was extracted from leukocytes and polymorphism was genotyped using real-time PCR discrimination assays. Statistical analyzes were performed using SPSS 22.0 and Python. Binary logistic regression was used to confirm associations after adjustments for confounding variables, as well as to perform an interaction analysis between the rs110402 polymorphism in the CRHR1 gene and childhood trauma. Results: Our sample had 42.9% (n=483) of individuals diagnosed with depression (current/or past), with a higher prevalence of the disorder in females (p
Databáze: OpenAIRE
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