Immunosenescence

Autor: Torres,Karen Cecília de Lima, Pereira,Patrícia de Araújo, Lima,Giselle Sabrina França de, Souza,Bruno Rezende, Miranda,Débora Marques de, Bauer,Moisés Evandro, Romano-Silva,Marco Aurélio
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Geriatrics, Gerontology and Aging v.5 n.3 2011
Geriatrics, Gerontology and Aging
Sociedade Brasileira de Geriatria e Gerontologia
instacron:SBGG
Popis: INTRODUCTION: Aging involves various complex cellular and molecular changes, including a general decline in immunological functions known as immunosenescence. The clinical consequences of immunosenescence include increased susceptibility to respiratory infections, neoplasias and cardiovascular diseases. OBJECTIVE: To review the major cellular and molecular changes in immunosenescence. METHODS: Literature review between 1996-2011 employing the PubMed and SciELO databases. RESULTS: With advancing age, the cells of the innate and adaptive immune system exhibit worsening of generalized function and a reduced number of naïve T cells. In addition, there is an expansion of certain clones of T lymphocytes (mainly CD8 +CD28- cells) that correlate with morbidity and mortality in the elderly. Besides the age-related impairments in cellular immune responses, aging is also associated with high serum inflammatory molecules and increased counts of circulating NK cells which is characterized by inflammaging. This framework can contribute to the pathogenesis and pathophysiology of inflammatory diseases such as atherosclerosis, Alzheimer's disease among others. In addition, during immunosenescence is also present a poor response to vaccines and increase in infectious diseases, tumors and autoimmunity. CONCLUSION: Understanding the relationship between the immune system and aging is of great importance to human health particularly on the impact of age-related diseases. It also helps to promote more effective and specific interventions for the elderly diseases.
Databáze: OpenAIRE
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