Eficacia y Seguridad de Regorafenib en Pacientes con Características de Buen Pronóstico en Tratamiento del Cáncer Colorrectal Metastásico: Análisis de Subgrupo del Estudio CORRECT

Autor: Palhares, Rodrigo Resende, Britto, Glauco do Canto, Su, Yun, Le Berre, Marie-Aude, Henriques, Ricardo Saad, Navachi, Fabricio Volpato, Pereira, Daniela Cristina Foli, Ostojic, Helene, Azevedo, Graziella Agostini, Van Cutsem, Eric
Jazyk: portugalština
Rok vydání: 2022
Předmět:
Zdroj: Revista Brasileira de Cancerologia; Vol. 68 No. 4 (2022): Oct./Nov./Dec.; e-162727
Revista Brasileira de Cancerologia; Vol. 68 Núm. 4 (2022): oct./nov./dic.; e-162727
Revista Brasileira de Cancerologia; v. 68 n. 4 (2022): out./nov./dez.; e-162727
Revista Brasileira de Cancerologia
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
ISSN: 2176-9745
Popis: Introduction: Colorectal cancer (CRC) is the second most common and when metastatic, it has a five-year survival rate of 14%. Regorafenib is an approved TKI for metastatic colorectal cancer (mCRC) with a proven increase in overall survival (OS). Objective: To investigate the efficacy and safety results of regorafenib in patients with mCRC and good prognostic characteristics (GPC). Method: Subgroup analysis of the CORRECT study, with participants divided according to GPC, following the criteria: Eastern Cooperative Oncology Group (ECOG) 0, duration of metastatic disease greater than 18 months, up to three metastatic sites and absence of liver metastasis. Efficacy compared with stratified log-rank test and hazard ratios (HR) calculated with the Cox model. Results: Of the 760 participants randomized, 292 (34.5%) had GPC; 185 (63.4%) received regorafenib; and 107 (35.6%) received placebo. For the GPC group, the median OS was 10.9 months (95%CI:8.8-12.3) for regorafenib and 7.3 months (95%CI:5.6-9.1) for placebo, with 39% of reduction of the risk of death (HR 0.61; 95% CI:0.43-0.88; p=0.0069). The median progression-free survival (PFS) was 3.5 months (95%CI:3.0-3.9) versus 1.8 months (95%CI:1.7-1.8) respectively, with 61% of reduced risk of disease progression or death (HR 0.39; 95%CI:0.30-0.52; p
Databáze: OpenAIRE
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