Effect of Bidens Pilosa against Carbon Tetrachloride-induced toxicity in wistar rats

Autor: PEGORARO, Cristiane Martinez Ruiz
Přispěvatelé: NAI, Gisele Alborghetti, CAMARGO FILHO, José Carlos Silva, GOMES, Homero Marques, ANJOLETTE, Fernando Antonio Pino, NOGUEIRA, Rosa Maria Barilli
Jazyk: portugalština
Rok vydání: 2018
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações da UNOESTE
Universidade do Oeste Paulista (UNOESTE)
instacron:UNOESTE
Popis: Submitted by Adriana Martinez (amartinez@unoeste.br) on 2018-05-10T22:56:59Z No. of bitstreams: 1 Cristiane.pdf: 2390262 bytes, checksum: 25e1f95e171ca5f09f8ad8d90cc4b3d9 (MD5) Made available in DSpace on 2018-05-10T22:56:59Z (GMT). No. of bitstreams: 1 Cristiane.pdf: 2390262 bytes, checksum: 25e1f95e171ca5f09f8ad8d90cc4b3d9 (MD5) Previous issue date: 2018-03-05 Carbon tetrachloride (CCl4) is a xenobiotic that can induce injury by the formation of free radicals. When administered it is distributed and deposited in organs such as liver, brain, kidney, lung and heart. Since ancient times, medicinal plants have been of great importance in human health. According to the World Health Organization, about 80% of the world's population uses medicinal herbs as the first health care. Bidens pilosa (BP), popularly known as “Picão”, is a plant native to South America. BP has been used over the years to treat many diseases, such as inflammation, immune disorders, digestive diseases, infectious diseases, cancers, metabolic syndrome, wounds and liver diseases. BP has constituents with antioxidant activity, such as flavonoids. Objective: The aim of this study was to evaluate if the topical and oral treatment with BP have a protective effect against the carbon tetrachloride (CCl4)-induced toxicity. Material and methods: We used 56 male Wistar rats divided into 6 groups: A (n = 10): CCl4 only; B (n = 10): CCl4 + oral aqueous extract of BP; C (n = 10): CCl4 and topical BP (daily shower/1minute); D (n = 10): CCl4 and oral and topical aqueous extract (daily bath/1minute) BP; E (n = 8): oral aqueous extract of BP; F (n = 8): olive oil. The dose of CCl4 and olive oil was 1 mL solution/kg intraperitoneally 2 weight times/week and oral BP dose was 0.5mL/100g by gavage daily for 10 weeks. Blood samples were collected for hepatic and renal function tests and fragments of liver, spleen, pancreas, kidney and small and large intestine for histopathological analysis. Results: Statistical differences between group A and the other groups were observed in the following parameters: GGT (gamma glutamyl transpeptidase) (p = 0.017), albumin (p = 0.002), urea (p = 0.009) and creatinine 0.009), hepatic inflammation (p = 0.0001), renal tubular lesion (p
Databáze: OpenAIRE
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