Prognostic value of functional polymorphisms in PON1, TNF-α and TGF-β genes in oral and oropharyngeal squamous cell carcinoma
| Autor: | Santana, Ingrede Tatiane Serafim |
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| Přispěvatelé: | Matos, Felipe Rodrigues de |
| Jazyk: | portugalština |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFS Universidade Federal de Sergipe (UFS) instacron:UFS |
| Popis: | Oral and oropharyngeal squamous cell carcinoma (OOSCC) is a malignant neoplasm of epithelial origin that accounts for 90 to 95% of tumors in oral cavity. Alcohol and tobacco consumption are main risk factors, but the formation of reactive oxygen species (ROS) and presence of chronic inflammatory processes have been shown to favor the carcinogenesis process. Human serum paraoxonase 1 (PON1) is a protein with an important antioxidant action and prevents oxidative stress induced by ROS, in turn, high levels of tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) are commonly found in inflammatory processes, and changes in these proteins have been related to development of different neoplasms. Present study aims to investigate the prognostic value of functional polymorphisms in PON1, TNF-α and TGF-β genes in OOSCC. This is a prospective cohort study with patients attended at the Advanced Oncology Center of the North-Riograndense League against Cancer. Data collection of clinical variables was done through the form: gender, age, tumor site, TNM (primary tumor, regional nodule and distant metastasis) classification, clinical stage; and through interview: smoking habits and alcohol intake by the patient. A total of 163 samples from patients with OOSCC and 146 control samples were genotyped by real-time PCR. It was observed that 76.1% of the population was males, 84% older than 52 years, with a more frequent intra-oral clinical presentation (53.4%), in the tongue region (21.5%), tumors greater than 4cm (56.45%), presence of nodal involvement (58.9%) and stages III and IV (79.15%). There was a positive association between drinking and smoking habits in patients with OOSCC and between clinical stage and tumor site (p |
| Databáze: | OpenAIRE |
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