Investigation of the carcinogenic potential of atmospheric exposure to trivalent chrome powder in Rattus norvegicus
| Autor: | Teixeira, Justijânio Cácio Leal |
|---|---|
| Přispěvatelé: | Monteiro, Helena Serra Azul |
| Jazyk: | portugalština |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC |
| Popis: | Chromium is a heavy metal and a well known environmental contaminant. Chromium (III) was initially considered a relatively non-toxic agent. On the other hand, evidence suggests that this metal may contribute to mutations in genetic material and induction of genetic instability, which in turn are determining factors for carcinogenesis processes. Thus, the present study aimed to evaluate the potential for induction of genomic instability and carcinogenesis from atmospheric exposure to chromium (III) dust in Rattus norvegicus. To this end, 40 animals were divided into two exposure groups: the exposed group (n = 20 males) were exposed for 4 h to atmospheric chromium (III) dust at a concentration of 500 µg/m3 daily for a total period of 14 weeks; The control group consisted of 20 animals (males) exposed to filtered air (HEPA) for an equal period of exposure. During the exposure period, the animals were evaluated for general toxicological, behavioral and locomotor parameters, as well as for the development of perceived or palpable lesions. In addition, analyzes of the antioxidant profile (catalase, superoxide dismutase and glutathione) were performed at the end of each week of exposure. Finally, blood samples were collected for biochemical and hematological processing, as well as lung, liver and kidney fragments were collected for histopathological analysis. In addition, bone marrow samples were collected for genotoxic evaluation, mutagenic profile and cell death analysis. Chromium (III) 500 µg/m3 produced no behavioral changes in exposed animals. On the other hand, chromium produced hitopathological changes in the liver, kidneys and lung. Also, it induced an increase (p |
| Databáze: | OpenAIRE |
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