The central role of Fas-ligand cell signaling in inflammatory lung diseases
| Autor: | DosReis, George Alexandre, Borges, Valeria de Matos, Zin, Walter Araujo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Macrophage
Silicosis Alvéolos Pulmonares/imunologia Apoptosis Injury Glicoproteínas de Membrana/fisiologia Macrófagos Alveolares/imunologia Fas ligand Antígenos CD95/imunologia Pneumonia/metabolismo Proteína Ligante Fas Neutrófilos/imunologia Phagocytosis Regulação da Expressão Gênica Doença Aguda Lung Inflammation Células Epiteliais/metabolismo Apoptose Fibrose Pulmonar/imunologia Transdução de Sinal Neutrophil Fibrosis Humanos Silicose/imunologia Pneumonia/imunologia Interleucina-1/metabolismo |
| Zdroj: | Repositório Institucional da FIOCRUZ (ARCA) Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| Popis: | Federal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil Federal University of Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil Following inflammation and injury in the lung, loss of epithelial cell precursors could determine the balance between tissue regeneration and fibrosis. This review discusses evidence that proapoptotic Fas-Fas ligand (FasL) signaling plays a central role in pulmonary inflammation, injury and fibrosis. FasL signaling induces inflammatory apoptosis in epithelial cells and alveolar macrophages, with concomitant IL-1 beta and chemokine release, leading to neutrophil infiltration. FasL signaling plays a critical role in models of acute lung injury, idiopathic pulmonary fibrosis and silicosis; blockade of Fas-FasL interactions either prevents or attenuates pulmonary inflammation and fibrosis. Serologic and immunohistochemical studies in patients support a major pathogenic role of Fas and FasL molecules in inflammatory lung diseases. Identification of the pathogenic role of FasL could facilitate the discovery of more effective treatments for currently untreatable inflammatory lung diseases |
| Databáze: | OpenAIRE |
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