The onset of psoriasis during the treatment of inflammatory bowel diseases with infliximab: Should biological therapy be suspended?
| Autor: | Denadai, Rafael [UNESP], Teixeira, Fábio Vieira [UNESP], Saad-Hossne, Rogério [UNESP] |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
corticosteroid psoriasis vulgaris corticosteroid therapy review mercaptopurine Inflammatory bowel disease methotrexate mycophenolic acid 2 morpholinoethyl ester remission systematic review Gastrointestinal Agents adalimumab plasmacytoid dendritic cell Psoriasis Humans Biological therapy human enteritis bibliographic database skin biopsy ulcerative colitis Embase azathioprine tumor necrosis factor alpha physician hyperkeratosis Crohn disease Medline Antibodies Monoclonal Inflammatory Bowel Diseases Infliximab alpha interferon cyclosporin certolizumab pegol parakeratosis spondylarthritis vitamin D derivative epithelium hyperplasia mesalazine disease exacerbation histopathology cytokine production Female etanercept acanthosis phototherapy |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-27T11:26:26Z No. of bitstreams: 0Bitstream added on 2014-05-27T14:36:41Z : No. of bitstreams: 1 2-s2.0-84863796295.pdf: 201307 bytes, checksum: 832442602596f761b69ec9b19a5aa347 (MD5) Made available in DSpace on 2014-05-27T11:26:26Z (GMT). No. of bitstreams: 0 Previous issue date: 2012-04-01 Context - Several paradoxical cases of infliximab-induced or-exacerbated psoriatic lesions have been described in the recent years. There is disagreement regarding the need to discontinue infliximab in order to achieve the resolution of these adverse cutaneous reactions specifically in inflammatory bowel disease (IBD) patients. Objective - To systematically review the literature to collect information on IBD patients that showed this adverse cutaneous reaction, focusing mainly on the therapeutic approach. Methods - A systematic literature review was performed utilizing Medline, Embase, SciELO and Lilacs databases. Published studies were identified, reviewed and the data were extracted. Results - Thirty-four studies (69 IBD patients) met inclusion criteria for review. There was inconsistency in reporting of some clinical and therapeutic aspects. Most patients included had Crohn's disease (89.86%), was female (47.83%), had an average age of 27.11 years, and no reported history of psoriasis (84.05%). The patients developed primarily plaque-type psoriasis (40.58%). There was complete remission of psoriatic lesions in 86.96% of IBD patients, existing differences in the therapeutic approaches; cessation of infliximab therapy led to resolution in 47.83% of cases and 43.48% of patients were able to continue infliximab therapy. Conclusion - As increasing numbers of IBD patients with psoriasis induced or exacerbated by infliximab, physicians should be aware of its clinical manifestations so that appropriate diagnosis and treatment are properly established. The decision whether to continue or discontinue infliximab should be individualized. Department of Surgery Botucatu Medical School University of the State of São Paulo (UNESP), Botucatu, SP Department of Surgery Botucatu Medical School University of the State of São Paulo (UNESP), Botucatu, SP |
| Databáze: | OpenAIRE |
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