Evaluation of gastrointestinal toxicity and transit of extracts and nematicidal fractions of moringa oleifera in mice
| Autor: | Braga, Ana Carolina Linhares |
|---|---|
| Přispěvatelé: | Graça, José Ronaldo Vasconcelos da, Salles, Hévila Oliveira |
| Jazyk: | portugalština |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Repositório Institucional da Universidade Federal do Ceará (UFC) Universidade Federal do Ceará (UFC) instacron:UFC |
| Popis: | Moringa oleifera is a plant with a high amount of molecules with related biological activities, attracting research to prove and justify its pharmacological use. As an example, the plant has been evaluated in the control of gastrointestinal nematodes in goats, parasites that cause production losses and available treatments (anthelmintics) trigger resistance in them. However, studies were lacking that evaluated the safety, the adequate dose and the actual gastrointestinal effects of fractions of the seeds of this plant with nematicidal activity. The objective of this study was to evaluate the acute, subchronic and gastrointestinal toxicity in mice of extracts and fractions of Moringa oleifera seeds with proven nematicidal activity. The crude aqueous extract (Exb) was produced from M. oleifera seeds with bark, lyophilized. To obtain the secondary compounds (C2) the EXB was fractionated with ethanol PA. After centrifugation the supernatant generated C2 and the pellet the protein fraction was fractionated by dialysis (D |
| Databáze: | OpenAIRE |
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