Journal of Natural Products
| Autor: | Gama, Kelly Barbosa, Quintans, Jullyana de Souza Siqueira, Antoniolli, Ângelo Roberto, Quintans Júnior, Lucindo José, Santana, Wagno Alcântara de, Branco, Alexsandro, Soares, Milena Botelho Pereira, Villarreal, Cristiane Flora |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1021/np3007342 |
| Popis: | Texto completo: acesso restrito. p. 559−563 Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-11-25T14:30:51Z No. of bitstreams: 1 Kelly Barbosa Gama.pdf: 623352 bytes, checksum: 775057950bf26281a03c9d6374ade542 (MD5) Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-12-01T20:40:03Z (GMT) No. of bitstreams: 1 Kelly Barbosa Gama.pdf: 623352 bytes, checksum: 775057950bf26281a03c9d6374ade542 (MD5) Made available in DSpace on 2014-12-01T20:40:03Z (GMT). No. of bitstreams: 1 Kelly Barbosa Gama.pdf: 623352 bytes, checksum: 775057950bf26281a03c9d6374ade542 (MD5) Previous issue date: 2013 Hecogenin is a sapogenin present in the leaves of species from the Agave genus, with a wide spectrum of reported pharmacological activities. The present study was undertaken to evaluate whether hecogenin acetate (1) has antinociceptive properties and to determine its mechanism of action. The nociceptive threshold was evaluated using the tail flick test in mice. Mice motor performance was evaluated in a Rotarod test. By using Fos expression as a marker of neural activation, the involvement of the periaqueductal gray in 1-induced antinociception was evaluated. Intraperitoneal administration of 1 (5–40 mg/kg) produced a dose-dependent increase in the tail flick latency time compared to vehicle-treated group (p < 0.01). Mice treated with 1 (40 mg/kg) did not show motor performance alterations. The antinociception of 1 (40 mg/kg) was prevented by naloxone (nonselective opioid receptor antagonist; 5 mg/kg), CTOP (μ-opioid receptor antagonist; 1 mg/kg), nor-BNI (κ-opioid receptor antagonist; 0.5 mg/kg), naltrindole (δ-opioid receptor antagonist; 3 mg/kg), or glibenclamide (ATP-sensitive K+ channel blocker; 2 mg/kg). Systemic administration of 1 (5–40 mg/kg) increased the number of Fos positive cells in the periaqueductal gray. The present study has demonstrated for the first time that 1 produces consistent antinociception mediated by opioid receptors and endogenous analgesic mechanisms. |
| Databáze: | OpenAIRE |
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