Bromocriptine at lactation attenvates the deleterious effects of early weaning

Autor: Silva, Nayara Peixoto
Přispěvatelé: Araújo, Patrícia Cristina de Aragão, Moura, Egberto Gaspar de, Resende, Angela de Castro, Henriques, João Antonio Pêgas, Fortunato, Rodrigo Soares, Oliveira, Elaine de
Jazyk: portugalština
Rok vydání: 2015
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações da UERJ
Universidade do Estado do Rio de Janeiro (UERJ)
instacron:UERJ
Popis: Submitted by Boris INFORMAT (boris@uerj.br) on 2021-04-26T01:11:38Z No. of bitstreams: 1 Nayara Peixoto Silva Tese completa.pdf: 3747455 bytes, checksum: bb491eae9009709b750e01b0bfeb3766 (MD5) Made available in DSpace on 2021-04-26T01:11:38Z (GMT). No. of bitstreams: 1 Nayara Peixoto Silva Tese completa.pdf: 3747455 bytes, checksum: bb491eae9009709b750e01b0bfeb3766 (MD5) Previous issue date: 2015-02-27 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior As non-pharmacological early weaning (EW) programs the offspring to obesity, liver microsteatosis and increased oxidative stress in adulthood, and the pharmacological EW, inhibiting the prolactin with a dopamine agonist (bromocriptine), also cause obesity in this study we aim to: (1) verify the redox status and hepatic function in the programming model of pharmacological EW. As bromocriptine has protective effects on glucose homeostasis in adult animals, we hypothesized that it could interfere with the programming of non-pharmacological EW and to test it we aimed: (2) to evaluate the potential interference of this drug in programming through its application in the offspring submitted to non-pharmacological EW; (3) to evaluate the long-term effects of treatment of a hyperlipidic diet. Experiment 1: lactating rats were divided into 2 groups: EW (BROMO) in which the mothers were treated i.p. with 1 mg / day of bromocriptine in the last 3 days of lactation; Control (C) whose mothers received similar treatment with vehicle solution. The offspring were evaluated at 90 and 180 days old (P90 and P180). The differences were analyzed through Student's t-test (significance P
Databáze: OpenAIRE
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