In silico analysis for identification of tick phagotopes selected by phage-displayed libraries

Autor:	Prudencio,Carlos Roberto, Nascimento,Rafael, Marchiori Filho,Moacir, Marra,Andrea de Oliveira Marques, Souza,Guilherme Rocha Lino de, Almeida,Juliana Franco, Cardoso,Rone, Szabó,Matias Pablo Juan, Goulart,Luiz Ricardo
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	phagotopes fungi parasitic diseases bioinformatics phage display vaccines tick
Zdroj:	Revista Brasileira de Parasitologia Veterinária v.18 n.1 2009 Revista Brasileira de Parasitologia Veterinária Colégio Brasileiro de Parasitologia Veterinária (CBPV) instacron:CBPV
Popis:	Phage display techniques have been widely employed to map epitope structures which have served as the basis for developing molecular vaccines. We have applied this technique to map specific epitopes of Rhipicephalus (Boophilus) microplus. In the present study, we have identified the potential immunogens using a process in which the selected phage clones were analyzed through bioinformatics, prior to final field tests. The present study demonstrates the feasibility of identifying important R. (B.) microplus phagotopes for vaccine development through screening of phage-displayed random peptide libraries and bioinformatics tools.
Databáze:	OpenAIRE
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