Study of simpatovagal balance and effects of pimobendan in the heart rate variability in dogs with heart failure by degenerative chronic valvular mitral disease under treatment

Autor: Trindade, Daniel de Castro
Přispěvatelé: Olivares, Emerson Lopes, Fortes, Fabio Silva de Azevedo, Miranda, Amarildo, Silveira, Anderson Luiz Bezerra da, Paiva, Jonimar Pereira
Jazyk: portugalština
Rok vydání: 2015
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações da UFRRJ
Universidade Federal Rural do Rio de Janeiro (UFRRJ)
instacron:UFRRJ
Popis: Submitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2017-04-11T21:02:55Z No. of bitstreams: 1 2015 - Daniel de Castro Trindade.pdf: 4241082 bytes, checksum: 050e5970f8afecacd5ab5af40fcf6348 (MD5) Made available in DSpace on 2017-04-11T21:02:55Z (GMT). No. of bitstreams: 1 2015 - Daniel de Castro Trindade.pdf: 4241082 bytes, checksum: 050e5970f8afecacd5ab5af40fcf6348 (MD5) Previous issue date: 2015-07-29 The heart rate variability (HRV) consist in a method able of assess the modulation of the autonomic nervous system (ANS) on the heart, allowing to determine possible simpatovagal changes. The analysis of time and frequency domain are types of signal processing used to investigate this variability, both dependent of the measures of RR intervals. The aim of this study was to evaluate the simpatovagal balance through HRV analysis by Holter method in dogs with valvar disease submitted to convencional drug therapy for heart failure or associate with Pimobendan. We used 37 adult dogs (13 males and 24 females), 03-14 years old and different breeds constituting 03 groups: CONT (healthy dogs without any treatment); CTP (dogs with heart failure receiving conventional therapy for CHF) and CTP + Pimo (dogs with heart failure receiving conventional therapy for CHF, associated with Pimobendan). The Holter examination was performed in different veterinary clinics in the Rio de Janeiro state, lasting 30 minutes and after a minimum period of 30 days from starting treatment. The parameters studied were: minimum heart rate; mean; maximum and QRS number. In the time domain were studied values: NN mean, SDNN, SDANN, SDNN index, rMSSD and pNN50. In the frequency domain the values studied were: Fc; HF; LF; VLF; LF / HF. Statistical values were showed as mean ? sem. The mean values of minimum heart rate, mean, maximum and QRS complex number of the different groups showed no statistical significance (P> 0.05). The mean values of the study of HRV in the time domain, the CTP and CTP + Pimo groups showed significant reduction (P 0,05). Nos valores m?dios do estudo da VFC no dom?nio do tempo, os animais dos grupos CTP e CTP + Pimo apresentaram redu??o significativa (P < 0,05) dos seguintes par?metros (SDNN; SDANN; SDNNIDX; RMSSD e pNN50) vs grupo CONT. No dom?nio da frequ?ncia, os grupos CTP e CTP + Pimo mostraram valores significativamente inferiores da pot?ncia total de espectro vs CONT (P < 0,05); menores valores de LF do grupo CTP vs grupo CONT (P < 0,05); maiores valores de LF do grupo CTP + Pimo vs CTP (P < 0,05), menores valores de VLF do grupo CTP + Pimo vs CONT (P < 0,01); menores valores da raz?o LF/HF do grupo CTP vs CONT (P < 0,05) e maiores valores para CTP + Pimo vs CTP (P< 0,01). Nosso estudo mostrou mudan?as significativas da redu??o da VFC nos dom?nios do tempo e da frequ?ncia nos grupos CTP e CTP + Pimo quando comparados ao grupo CONT. Por?m, c?es tratados com Pimobendan n?o mostraram evid?ncia significativa em melhora de seus par?metros da VFC quando comparado aos outros c?es cardiopatas que n?o receberam esta droga, pelo menos durante o per?odo proposto nesse estudo. As altera??es em par?metros da VFC em c?es cardiopatas foram capazes de se manter mesmo trabalhando com pacientes apresentando grande diversidade racial, de pesos, sexo e idade; mostrando valores significativamente inferiores nos dom?nios do tempo e frequ?ncia quando comparados aos c?es normais. A terapia com Pimobendan, ainda n?o descrita na literatura como capaz de influenciar par?metros da VFC em c?es cardiopatas, em nosso estudo mostrou que animais tratados com essa droga apresentaram maior modula??o simp?tica, comprovada atrav?s da rela??o LF/HF.
Databáze: OpenAIRE
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