Evaluation of the influence of the absorbance obtained in three wavelengths of low-density lipoprotein on its in vitro oxidation in pacients with diabetes mellitus type-1
| Autor: | Pandini, Juliana Almeida |
|---|---|
| Přispěvatelé: | Gomes, Marilia de Brito, Silva, Adriana Ribeiro, Avesani, Carla Maria, Oliveira, Cecilia Lacroix de |
| Jazyk: | portugalština |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Biblioteca Digital de Teses e Dissertações da UERJ Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
| Popis: | Submitted by Boris Flegr (boris@uerj.br) on 2021-01-06T20:58:52Z No. of bitstreams: 1 JULIANA PANDINI.pdf: 960977 bytes, checksum: a37caafc753ec6ed90af7b20a1803ea3 (MD5) Made available in DSpace on 2021-01-06T20:58:52Z (GMT). No. of bitstreams: 1 JULIANA PANDINI.pdf: 960977 bytes, checksum: a37caafc753ec6ed90af7b20a1803ea3 (MD5) Previous issue date: 2009-12-15 Conselho Nacional de Desenvolvimento Científico e Tecnológico With the intensive glycemic control and longer survival of type 1 diabetes mellitus (T1DM) patients, cardiovascular disease has been the main cause of mortality. Oxidized LDL is considered a critical factor in the atherosclerotic process and the aim of our study was evaluate the absorbance of different wavelengths of oxidized phospholipids and oxidation rate of LDL particles in vitro in T1DM. We studied 54 patients aged 29.1 ± 12.11 years and with a disease duration of 14.6 ± 8.43 years and 28 non-diabetic volunteers. The two groups had carried where they were measured lipid profile, glucose, uric acid, blood pressure, urinary albumin excretion and spectrophotometry analysis of the oxidation of LDL cholesterol before and 1, 3, 6 and 24 hours after addition of substance oxidant copper sulfate. The coefficients of oxidation (Cox) of LDL from both groups had similar reading at all times with a significant difference between the baseline and after 1 hour (p |
| Databáze: | OpenAIRE |
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