Effect of the extract of Morus Nigra L. on treatment of vasomotor symptoms in women with climacteric syndrome - one randomized, placebo - controlled study

Autor: COSTA, Joyce Pinheiro Leal
Přispěvatelé: BRITO, Luciane Maria Oliveira, BRITO, Haissa Oliveira, BACCARO, Luiz Francisco Cintra, BORGES, Marilene Oliveira da Rocha, FIGUEIREDO, Patricia de Maria Silva, NASCIMENTO, Maria do Desterro Soares Brandão
Jazyk: portugalština
Rok vydání: 2018
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações da UFMA
Universidade Federal do Maranhão (UFMA)
instacron:UFMA
Popis: Submitted by Daniella Santos (daniella.santos@ufma.br) on 2019-01-16T14:55:17Z No. of bitstreams: 1 JoyceCosta.pdf: 2418930 bytes, checksum: 8d3219294f4a23f5cb874c7dea861ca5 (MD5) Made available in DSpace on 2019-01-16T14:55:17Z (GMT). No. of bitstreams: 1 JoyceCosta.pdf: 2418930 bytes, checksum: 8d3219294f4a23f5cb874c7dea861ca5 (MD5) Previous issue date: 2018-07-02 CAPES FAPEMA Introduction: Hormone replacement therapy (HRT) is the standard treatment for climacteric symptoms; however, there are contraindications to its use. In this context, the use of phytoestrogens has been a common practice, since they decrease the incidence of these symptoms. There are no clinical data about the use of Morus nigra L. for the treatment of climacteric symptoms. Objective: To compare the efficacy of leaf extract of Morus nigra L. for the treatment of climacteric symptoms with HRT (standard comparative group) and a placebo group (simple control). Methods: A randomized (computer generated), double-blind clinical trial was performed with 62 climacteric women, divided into three groups: Morus nigra (MN) Group - capsule with Morus nigra L. powder 250 mg (n = 20), HRT-estradiol 1 mg or estradiol 1 mg + norethisterone acetate 0.5 mg (n = 20) and Placebo (n = 22) for 60 days. The response variable was the mean score of the Blatt-Kuppermann Index (BKI). Quality of life (QoL) through the SF-36 questionnaire, oncotic colpocitology, colposcopy and biochemical and hormonal dosages were also evaluated (fasting glycemia, HDL, LDL, triglycerides, total cholesterol, AST, ALT, urea, creatinine, uric acid, alkaline phosphatase, ultra-sensitive RCP, estradiol, FSH, TSH and free T4). The level of significance was set at 5% and analysis performed by intention to treat (ITT). Data were analyzed using SPSS 25.0 software. Results: The groups presented a homogenous sociodemographic profile, close to 50 years of age, brown, full high school, general services auxiliary, without alcoholism, or smoking, and did not have regular practice of physical activity. There was a mean reduction in BKI scores in the MN group (18.0 for 10.0, p
Databáze: OpenAIRE
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