Contraception
| Autor: | Fotherby, K., Akpoviroro, J., Abdel-Rahman, H. A., Toppozada, H. K., Souza, J. Caetano de, Coutinho, Elsimar Metzker, Koetsawang, S., Nukulkarn, P., Sheth, U. K., Napa, M. K., Gopalan, S., Plunkett, E. R., Brenner, P. F., Hickey, M. V., Grech, E. S., Lichtenberg, R., Gual, C., Molina, R., Gomez-Rogers, C., Kwon, E., Kim, S. W., Chan, T., Ratnam, S. S., Landgren, B. M., Shearman, R. P., Goldzieher, J. W., Dozier, T. S. |
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| Jazyk: | angličtina |
| Rok vydání: | 1981 |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1016/0010-7824(81)90076-7 |
| Popis: | Texto completo. Acesso restrito. p. 487 – 496 Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-02-21T19:41:54Z No. of bitstreams: 1 555555ssss.pdf: 521276 bytes, checksum: 2a4883726b7d7d88edcc597f9211558a (MD5) Approved for entry into archive by Rodrigo Meirelles(rodrigomei@ufba.br) on 2013-02-21T19:53:19Z (GMT) No. of bitstreams: 1 555555ssss.pdf: 521276 bytes, checksum: 2a4883726b7d7d88edcc597f9211558a (MD5) Made available in DSpace on 2013-02-21T19:53:19Z (GMT). No. of bitstreams: 1 555555ssss.pdf: 521276 bytes, checksum: 2a4883726b7d7d88edcc597f9211558a (MD5) Previous issue date: 1981 The pharmacokinetics of a dose of 501I g eth:nyloestradiol administered orally was studied in fourteen centres. lbsorption lr'arsa pid and the highest serum concentrations of total ethynyloestradiol were found in .,ost subjects at 1 h and by $4 h concentrations were less than 250 p:/':.l. Calculation of the half-lives for absorption, distribution and elildnation showed wide variations between subjects, the half-life of elimination varying from 2.; h to more than n0 h. Bioavailability as mensured by the area under the serum ethynyloestradiol concentration-tiniec urve also showed more th.an a ten-fold variation. Intra-centre differences in the various parameters measured were as large as the inter-centre differerccs. |
| Databáze: | OpenAIRE |
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