Revista de Ciências Médicas e Biológicas
| Autor: | Tatfeng, Y. M., Agbonlahor, D. E., Amegor, O. F. |
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| Jazyk: | portugalština |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| Popis: | Keywords: Cytokines – Childhood haemoglobinopathies - Uncomplicated malaria Submitted by ROBERTO PAULO CORREIA DE ARAÚJO (ppgorgsistem@ufba.br) on 2017-06-01T19:19:36Z No. of bitstreams: 1 3_v.9_1.pdf: 117477 bytes, checksum: cefe0188d16f52e415231a998f92a104 (MD5) Made available in DSpace on 2017-06-01T19:19:36Z (GMT). No. of bitstreams: 1 3_v.9_1.pdf: 117477 bytes, checksum: cefe0188d16f52e415231a998f92a104 (MD5) Previous issue date: 2010-01 The relative balance between Th1 and Th2 cytokines appears crucial in the outcome of infections. We assayed some Th1 cytokines (interleukin-2 (IL-2) and gamma interferon (IFN-g) and Th2 cytokines (IL-4 and IL-10) in homozygous haemoglobin (Hb) AA, heterozygous HbAS genotyped and sickle cell (HbSS) individuals with uncomplicated P. falciparum malaria to determine the group with the strongest cytokine response to P. falciparum malaria. Levels of Th1 and Th2 cytokines of 111 children with uncomplicated malaria and 89 healthy controls were determined by Enzyme Linked Immunosorbent Assay and haematological parameters were estimated using standard haematological techniques. Th1 and Th2 cytokine levels were significantly higher in HbAA, HbAS genotyped patients compared to their respective healthy controls (P |
| Databáze: | OpenAIRE |
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