Clinical impact of Achromobacter xylosoxidans infection in cystic fibrosis
| Autor: | Fírmida, Mônica de Cássia |
|---|---|
| Přispěvatelé: | Lopes, Agnaldo José, Marques, Elizabeth de Andrade, Sant'anna, Clemax Couto, Higa, Laurinda Yoko Shinzato, Costa, Cláudia Henrique da, Leão, Robson de Souza |
| Jazyk: | portugalština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Biblioteca Digital de Teses e Dissertações da UERJ Universidade do Estado do Rio de Janeiro (UERJ) instacron:UERJ |
| Popis: | Submitted by Boris Flegr (boris@uerj.br) on 2021-01-05T19:37:13Z No. of bitstreams: 1 Monica de Cassia Firmida Tese Completa.pdf: 8157863 bytes, checksum: a56be670f9e927b179e26b282905b4c6 (MD5) Made available in DSpace on 2021-01-05T19:37:13Z (GMT). No. of bitstreams: 1 Monica de Cassia Firmida Tese Completa.pdf: 8157863 bytes, checksum: a56be670f9e927b179e26b282905b4c6 (MD5) Previous issue date: 2016-11-23 The frequency of Achromobacter xylosoxidans infection in cystic fibrosis has increased in recent years. However, the clinical impact of the infection with this microorganism is still controversial. This retrospective study aimed to evaluate the clinical impact of A. xylosoxidans infection in three groups of patients with cystic fibrosis: chronically (n = 10), intermittently (n = 15) and never infected individuals (n = 18), all also chronically infected with Pseudomonas aeruginosa. The three groups were transversely evaluated in two moments: at the time of A. xylosoxidans infection (M1) and two years later (M2). The group never infected with A. xylosoxidans was paired with the other two groups by age (± 1 year) and sex. Demographic data, clinical data, lung function, and chronic bacterial coinfections were evaluated. Of the total study population, 87% were under 18 years and 65.1% were female. Individuals chronically infected with A. xylosoxidans had lower volume forced expiratory in one second since the beginning of the study (51.7% in the group with chronic infection, 82.7% in the group with intermittent infection and 76% in the group not infected) and higher frequency of coinfection with methicillin-resistant Staphylococcus aureus (P = 0.002). In two years, the decline in lung function was not significant in any of the three groups, although it has been observed tendency to significant decrease in the A. xylsosoxidans chronically infected group. The average of annual hospitalizations was also higher in this group (P = 0.033). In summary, A. xylosoxidans infection was more common in pediatric patients ( |
| Databáze: | OpenAIRE |
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