Prevalence of oral HPV infection and association of GST polymorphisms in HIV-positive patients

Autor: Trevisan, Marcela Gonçalves
Přispěvatelé: Lucio, Léia Carolina, Ferreto , Lirane Elize Defante, Benedetti, Volmir Pitt
Jazyk: portugalština
Rok vydání: 2022
Předmět:
Zdroj: Biblioteca Digital de Teses e Dissertações do UNIOESTE
Universidade Estadual do Oeste do Paraná (UNIOESTE)
instacron:UNIOESTE
Popis: Submitted by Almir Squinsani (almir.squinsani@unioeste.br) on 2023-02-02T19:59:45Z No. of bitstreams: 2 Marcela_Trevisan_2022.pdf: 2080654 bytes, checksum: 63e81a723b58ae773aef0ec5874ea935 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Made available in DSpace on 2023-02-02T19:59:45Z (GMT). No. of bitstreams: 2 Marcela_Trevisan_2022.pdf: 2080654 bytes, checksum: 63e81a723b58ae773aef0ec5874ea935 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2022-12-19 Human papillomavirus (HPV) infection is widely found in different population groups. However, in the face of immunosuppression, it can manifest as a clinical disease and progress to cancer. Currently, the growing increase in oropharyngeal squamous cell carcinomas associated with HPV is notorious, and Brazil is among the countries with the highest incidence of malignant tumors of the oral cavity. Nevertheless, genetic polymorphisms in glutathione-S-transferase (GST) enzymes also contribute to tumor risk, worse pathological outcomes, and viral infections, including human immunodeficiency virus (HIV) and HPV. However, scientific evidence indicates that deletion of the GSTM1 and GSTT1 genes may be related to normal counts of CD4+ T lymphocytes in HIV patients, reducing the progression of the disease. Therefore, the objective of the study was to verify the prevalence of oral HPV infection in HIV-positive patients linked to a Specialized Assistance Service in Southwest Paraná and the association of GSTM1 and GSTT1 polymorphisms with HIV viral infection. The quantitative approach research was carried out between 2020 and 2022 in a Specialized Care Service in the Southwest of Paraná. Sampling was for convenience, using a closed questionnaire with sociodemographic, behavioral and clinical variables. Oral mucosa samples were collected by the researchers themselves for detection of HPV and GSTM1 and GSTT1 polymorphisms, respectively, via simple and multiplex PCR (Polymerase Chain Reaction). Data received descriptive statistical treatment including HPV prevalence and associations between genetic polymorphisms and HIV viral infection. Pearson Chi-square (X2) test was used for categorical variables, with results with p
Databáze: OpenAIRE
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