Diabetes Research and Clinical Practice
| Autor: | Lima, Maria de Lourdes, Cruz, Thomaz Rodrigues Porto da, Rodrigues, Luiz Erlon, Bomfim, Olívia, Melo, Juliana, Correia, Raquel, Porto, Mirna, Cedro, Alexandre, Vicente, Eliézer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Repositório Institucional da UFBA Universidade Federal da Bahia (UFBA) instacron:UFBA |
| DOI: | 10.1016/j.diabres.2008.11.019 |
| Popis: | Acesso restrito: Texto completo. p. 257-262 Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-05-11T13:37:05Z No. of bitstreams: 1 __ac.els-cdn.com_S016882...b740abb550b531830b4397496ef67.pdf: 214812 bytes, checksum: 22c975faf65f8acdd565963621a1e08d (MD5) Made available in DSpace on 2012-05-11T13:37:05Z (GMT). No. of bitstreams: 1 __ac.els-cdn.com_S016882...b740abb550b531830b4397496ef67.pdf: 214812 bytes, checksum: 22c975faf65f8acdd565963621a1e08d (MD5) Previous issue date: 2009 This cross sectional study evaluated serum (SMg) and intramononuclear (MMg) magnesium in patients with metabolic syndrome without diabetes and correlated them with cardiovascular risk factors. 72 patients and 57 controls (blood donors) were studied. Hypomagnesemia (SMg < 1.7 mg/dL) was seen in 23.2% and intracellular depletion in 36.1% of the patients. SMg and MMg means were significantly lower in patients than in controls: 1.80 0.18 mg/dL vs. 2.43 0.43 mg/dL and 0.98 0.55 mg/mg vs. 1.67 0.64 mg/mg of protein (P < 0.001). Inverse correlation was observed between, SMg and MMg with BMI; SMg with systolic blood pressure and waist circumference in women. Patients with acanthosis nigricans had lower SMg (1.75 0.18 mg/dL vs. 1.85 0.18 mg/dL, P < 0.05). Non-white people had lower SMg (1.78 0.16 mg/dL vs. 1.92 0.24 mg/dL, P = 0.007) and MMg (0.95 0.59 mg/mg vs. 1.13 0.42 mg/mg, P = 0.03). Patients with IR showed lower MgM means (0.84 0.33 mg/mg vs. 1.14 0.69 mg/mg, P < 0.05). The same occurred in patients with low HDL-c levels (0.92 0.46 mg/mg vs. 1.20 0.70 mg/mg, P = 0.03), and those with moderate and severe hepatic steatosis (0.77 0.29 mg/mg vs. 1.21 0.80 mg/mg, P < 0.05). In conclusion, magnesium depletion in serum and mononuclear cells is common in obese people with metabolic syndrome, and it is more evident in non-white people with insulin resistance. This depletion may contribute to a post-receptor insulin resistance |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|