| Autor: |
Zablockaitė, Danguolė, Gendvilienė, Vida, Mačianskienė, Regina, Skeberdis, Vytenis Arvydas, Jurevičius, Jonas, Kanaporis, Giedrius, Gurskaitė, Herta, Benetis, Rimantas |
| Jazyk: |
litevština |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
Medicina, 2005, t. 41, Nr. 5, p. 401-408 |
| ISSN: |
1010-660X |
| Popis: |
Summary. The purpose of the present study was to determine whether extracellular osmotic pressure modulates b2-adrenergic stimulation of the contraction force and L-type Ca2+ current in human atrial myocytes. Experiments were performed on human atrial trabeculae and myocytes isolated from the right atrium. We have studied the effect of salbutamol (SAL), a β²-adrenoceptor agonist, on peak tension (P), time to half peak tension (tc), time to half relaxation (tr), resting tension (contracture) (C) and L-type calcium current (ICaL) under isosmotic (345 mOsm) and hyperosmotic (525 mOsm in experiments for P, and 405 mOsm for ICaL) conditions. Salbutamol (10–8÷10–5 M) added to the control solution increased P, with a half-stimulation constant EC50=(2.7±0.6)×10-8 M (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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