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Research problem. The patient's perception of his or her illness is one of the most important aspects in the development of an individual treatment plan, increasing the patient's motivation to treatment adherence, changing the lifestyle, improving emotional well-being and achieving the best health-related outcomes. However, the studies on perception and its changes during acute cardiological conditions are scarce. The aim of this study was to evaluate the perception of acute coronary syndrome and its changes 6 months after cardiac rehabilitation, in association with psychological, social and clinical factors. Participants. The study sample included 195 in-patients with acute coronary syndrome at cardiac rehabilitation, aged 27–89 years at baseline; 175 of them (response rate 90%) participated in follow-up assessment 6 months later. Methods. The cohort study was conducted with assessments at the beginning of cardiac rehabilitation (baseline) and 6 months later. The instrument was anonymous questionnaire comprising BIPQ scale for illness perception, DS14 scale for Type D personality, CDS scale for cynical distrust, LPGS Optimism subscale, MSPSS scale for perceived social support as well as clinical and demographic data. The data were analysed using univariate and bivariate as well as linear and logistic regression analysis. Results. At baseline, the perception of illness timeline was rated as the most threatening dimension, while that of treatment control – the least. It was found that women, older people, patients with poorer functional status (NYHA classification) and with comorbidities perceived their disease as more threatening (p |