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Aim of the study: to determine expression levels of molecular markers affected by infectious or non-infectious systemic inflammation (SI) and their relation to the disease features. Results: expression levels of miR-30d-5p, miR-146a-5p, miR-23a-3p are lower in infectious (peritonitis) SI and the most significant downregulation occurs at 24 - 48 h. after the onset of symptoms; levels of miRNA expression are not related to the peritonitis severity, but deterioration is associated with increasing estimates of RDW and CRP. The following relations may influence the course of peritonitis: the decrease in MAP is associated with a downregulation of miR-30d-5p expression; insufficient iv fluid prior to surgery increases administration of vasopressors during surgery; the volume of iv fluid before surgery is related to the MAP during surgery; the comorbid nervous system disease, decrease of preoperative MAP increase the mortality risk for patients with peritonitis. Expression levels of previously mentioned miRNA are lower in non-infectious ST-elevated myocardial infarction (STEMI) SI compared with controls. The downregulation of miR-23a-3p is significantly negatively correlated with severity of disease. Levels of miRNA expression are not associated with values of inflammatory markers in STEMI. Analyzed miRNAs provide poor discrimination between infectious (peritonitis) and non-infectious (STEMI) SI. Levels of miRNA expression are not associated with fatal outcomes in the early stage of STEMI. |
