| Popis: |
Objective: The purpose of this study was to perform a systematic literature review to evaluate the reported outcomes with the use of pentoxifylline, tocopherol, and clodronate in management of ORN. Methods: The data research was performed on PubMed and ScienceDirect for Text Word and Mesh termer, and English studies from 2009 until 2019 were chosen. The database search was done using the following keywords; pentoxifylline, tocopherol, and clodronate, and resulted in 113 studies. Screening of titles, abstracts, and full-texts was done. Five reviews that met the inclusion criteria were evaluated and submitted for data extraction. Results: A total of 5 articles, with a total of 227 participants were included in this systematic review. The majority of the materials had an agreement on their results. The combination of pentoxifylline plus tocopherol with or without clodronate was found to be useful for the treatment of osteoradionecrosis. Conclusion: Treatment with pentoxifylline and tocopherol and clodronate has a useful role in the management of early and moderate stages of ORN. The combination of these drugs appears to be safe and well-tolerated as it showed minimal side effects. However, the results need to be confirmed with further randomized clinical trials. Keywords: osteoradionecrosis, pentoxifylline, tocopherol, clodronate |
