Creation, analysis and antianemic action of peroral powders with ferrous oxalate. Ferosol-2

Autor: Nenortienė, Palma, Sapragonienė, Marija, Stankevičius, Antanas, Matusevičius, Algimantas Petras, Daunoras, Gintaras
Jazyk: litevština
Rok vydání: 2002
Předmět:
Zdroj: Medicina, 2002, t. 38, Nr. 1, p. 69-76
ISSN: 1010-660X
Popis: Experiments with piglets showed good assimilation and metabolism of iron (II) in antianemic powder Ferosol–1. In order to improve this drug, manganese, calcium (Ferosol–2, 1 composition) and ascorbic acid (Ferosol–2, 2 composition) were added. Manganese and ascorbic acid stimulate erythropoesis and being strong reductants stabilize iron (II) on storage and in gastrointestinal tract. Components of Ferosol–2 were identified using colour, precipitation- and extraction tests, as well as paper chromatography and absorption spectroscopy. Quantitative analysis of microelements and ascorbic acid was performed using absorption spectroscopy, extraction photometry and iodometric titration methods. Ferosol–2 proved to be more stable than Ferosol–1. Lichfield and Wilkinson method modificated by Roth was used for detection of acute toxicity of Ferosol– 2. A local action was estimated on quine pigs. Iron resorption was on 20 days old piglets. Antianemic effectiveness of Ferosol–2 was evaluated on newborn piglets watching their weight. Experiments with white mice showed low toxicity of Ferosol–2 (LD50=4.3 g/kg, for 1 composition and 4.6 g/kg for 2 composition). It does not irritate mucosa of duodenum and ventriculus. Iron in Ferosol–2 was found to be well assimilated in gastrointestinal tract of piglets, easily gets into blood and joins albumen of plasma. After administration of Ferosol–2 to piglets increased iron concentration in blood serum was observed for 3 hours (1 composition) and 6 hours (2 composition). Experimental data showed increased resorbtion of iron in Ferosol–2, 2 composition due to ascorbic acid. Components of Ferosol–2 are well assimilated and join erythropoetic processes. Ferosol–2 leads to quicker weight gain as well as significantly higher amount of hemoglobin and red blood cells in piglets.
Databáze: OpenAIRE
Externí odkaz: