Function of antioxidants during avian embryogenesis
| Autor: | GŁODEK K.B., LIS M.W., NIEDZIÓŁKA J.W. |
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| Jazyk: | ruština |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького. |
| ISSN: | 2518-1327 2413-5550 |
| Popis: | Development of avian embryo is running out of the mother’s organism. That makes him sensitive to stress caused with incubation parameters disturbances. Consequence of disturbance of embryo’s homeostasis is unphysiological increase of free radicals (FR) number. In life organisms the three levels antioxidative defense mechanism is functioning to protect lipids, proteins and nucleic acids against damages caused by FR. The first “preventive” level FR are neutralized with metalcoenzymes and enzymes cooperating with them like glutathione peroxidase, superoxide dismutase and catalase. The second “preventive therapeutic” level is made by such substances like riboflavin (vitamin B2),L (+) ascorbic acid (vitamin C), tocopherol (vitamin E), retinol (vitamin A) moreover gluthatione and uric acid. This substances inhibit the initiation phase, remove reactive oxygen sorts (ROS) and also prevent spreading of damages (inhibition of propagation phase). The third level depends on repairing and reconstructing damaged molecules with for example heat shocks proteins (HSP).Antioxidative mechanism’s function during bird’s embryogenesis was (has been) not fully checked yet. Based on previously acquired knowledge, it seems that it perform very important role. Evidence of this includes the fact that all the necessary antioxidant substances are a natural component of the egg (carotenoids, αtocopherol, selenium) or their synthesis begins in the first days of embryonic development (eg, ascorbic acid, glutathione, superoxide dismutase). The deficit of these compounds leads to impaired development and/or death of the embryo. For example, huge deficiency of riboflavin causes rapid death of chicken embryos between 10 and 13 day incubation as a result of accumulation of fatty acids oxidation process’s substrates, and hypoglycemia. Research on cognition of antioxidant system of avian embryos are carried out in numerous research centres, and the results obtained are applicable not only in animal science, but also in human medicine. Therefore, the aim of this work is to present the current state of knowledge on the role of antioxidant substances in bird embryo development. |
| Databáze: | OpenAIRE |
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