| Popis: |
Background: Cirrhosis hepatic is a chronicle progressive liver disease. The morphological changes of the injured liver cause damages with different intensity in his various functions. These damages directly affect the appearance of haemostatic disorders due to the liver role in the synthesis of clothing factors. Aims: To show the haemostatic disorders in patients with advanced disease stadium (ascites) who were treated in our Daily transfusion hospital and in the Internal ward Unit with plasma components (fresh frozen plasma and human albumin - 20%). Methods: From the Eastern part of Macedonia in the last five years, 103 patients were hospitalized and treated with plasma components and at the same time hematologic and biochemical analyzes were made of them. Also, haemostatic basic tests were made, such as: number of thrombocytes, the bleeding time( Duke), the prothrombine time ( Quick) shown as prothrombin activity in percent and INR, the thrombin time activated partial tromboplastin time (aPTT), capillary resistance and level of fibrinogen in serum. Reagents from Simens company were used. Results: In all these patients there was a decreased number of thrombocytes under 150x109/L (in range of 90-115 x109/L); the bleeding time (Duke) mildly extended up to normal ( 3-6min.); protrombin time (Quick) strongly extended from 25,5 to 27,5 sec. or (45 to 40 %) and INR from 2,16 to 3,5; the thrombin time and aPTT were in normal range; capillary resistance positive with 2++ and fibrinogen level in serum under normal (1-2g/L). Conclusions: With the disease advancement of hepatic cirrhosis, the haemostatic disorders become more and more manifested. Brushings and bleedings are present due to the decreased productions of factors of prothrombine complex and also decreased thrombopoietin from progressive hepatosplenomegaly. |
