| Autor: |
Taylor, S., Gafton, J., Shah, B., Pagano, G., Chaudhuri, K R, Brooks, D.J., Pavese, N. |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Taylor, S, Gafton, J, Shah, B, Pagano, G, Chaudhuri, K R, Brooks, D J & Pavese, N 2016, ' Progression of nonmotor symptoms in subgroups of patients with non-dopamine-deficient Parkinsonism ', Movement Disorders, vol. 31, no. 3, pp. 344-351 . https://doi.org/10.1002/mds.26456 |
| Popis: |
BackgroundTen to fifteen percent of Parkinson's disease (PD) patients recruited to clinical trials have scans without evidence of dopaminergic deficit, whose presence represents a heterogeneous patient population.MethodsA cohort of 41 patients with parkinsonism and scans without evidence of dopaminergic deficit at baseline, were subdivided into groups according to their final clinical diagnoses and nigrostriatal dopamine function assessed after 2 years of study. At follow up, 23 patients had clinically probable PD or unclassified parkinsonism with normal nigrostriatal dopamine imaging (true scans without evidence of dopaminergic deficit), nine were diagnosed with another tremulous condition, five had psychogenic parkinsonism, and four had phenoconverted to PD with reduced nigrostriatal dopamine function. We analyzed nonmotor symptoms at baseline and follow-up in subgroups of patients with scans without evidence of dopaminergic deficit in comparison with a random sample of 62 PD patients and 195 healthy controls (HCs). All patients were enrolled in the Parkinson's Progressive Marker's Initiative.ResultsPatients who had true scans without evidence of dopaminergic deficit had more severe rapid eye movement sleep disorder, depression, anxiety, and autonomic dysfunction than HCs in addition to more frequent depressive symptoms and worse cardiovascular dysfunction than patients with PD (P=0.038, P=0.047, respectively). Patients with true scans without evidence of dopaminergic deficit had normal olfaction that was significantly better than that of patients with PD (PConclusionsAt an early symptomatic stage, patients with scans without evidence of dopaminergic deficit and long-standing parkinsonism exhibit nonmotor features that differ from those of patients with PD on mood and cardiovascular and olfactory function, but remain similar to patients with scans without evidence of dopaminergic deficit with alternative final diagnoses. (c) 2016 International Parkinson and Movement Disorder Society |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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