| Autor: |
Edwards, Sylvia F., Moore, Amelia E.B., Fogelman, Ignac, Frost, Michelle L. |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Zdroj: |
Edwards, S F, Moore, A E B, Fogelman, I & Frost, M L 2018, ' The Evaluation of Vertebral Fracture Assessment and Pulse Wave Velocity for the Assessment of Abdominal Aortic Calcification by Comparison to Computed Tomography ', vol. 2, no. 1, 3 . |
| Popis: |
Background: Abdominal aortic calcification (AAC) is a marker of subclinicalatherosclerosis. Computed tomography (CT) is the gold-standard method forquantifying vascular calcification (VC) but is limited by higher radiation exposureand cost. Vertebral fracture assessment (VFA) scans have been proposed as auseful imaging tool for the semi-quantitative assessment of AAC, as images ofthe aorta are captured on VFA scans. Pulse wave velocity (PWV) is a simple, noninvasive method of measuring aortic stiffness - a hallmark of atherosclerosis and ageing, with a reduction in normal aortic compliance. In this study we compared VFA and PWV with CT as the gold standard of diagnosis. Lateral VFA scans may be utilised as a secondary utility to detect VC in post-menopausal women with low bone density, and associations between PWV and VC measured using lateral VFA and CT may demonstrate how measures of VC correlate with aortic stiffness.Methods and results: Four hundred and forty-four healthy post-menopausalwomen with a mean age of 62 (6.4 SD) years had carotid to femoral PWVmeasurements, and lateral VFA of the thoracic and lumbar spine, concurrentlywith bone densitometry measurements (DXA), to quantify AAC. A subgroup ofone hundred and thirteen subjects underwent non-contrast, non-diagnostic,ungated CT scans of the chest and abdomen. Results showed AAC was presentin 78% of subjects as determined by CT, and 60% with lateral VFA scans. Thesensitivity of lateral VFA for detecting AAC was 55% and specificity was 48% witha PPV and NPV of 67% and 36% respectively for binary scores. Sensitivity andspecificity improved when CT scores were divided into tertiles with the greatestimprovement with scores ≥ 670 AU, ≥ 15304.4 AU and ≥ 0.335 cm3 for the Agatston, modified Agatston and Volume scores respectively. There were no independent associations observed between PWV and AAC measured using lateral VFA or VC measured using CT.Conclusion: Lateral VFA scans may provide a low radiation dose, and low-costalternative to CT for evaluating higher levels of AAC and can be performedconcurrently with bone densitometry assessments. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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