Towards male individualization with rapidly mutating Y-chromosomal STRs

Autor: Ballantyne, Kaye N, Ralf, Arwin, Aboukhalid, Rachid, Achakzai, Niaz M, Anjos, Maria J, Ayub, Qasim, Balažic, Jože, Ballantyne, Jack, Ballard, David J, Berger, Burkhard, Bobillo, Cecilia, Bouabdellah, Mehdi, Burri, Helen, Capal, Tomas, Caratti, Stefano, Cárdenas, Jorge, Cartault, François, Carvalho, Elizeu F, Carvalho, Monica, Cheng, Baowen, Coble, Michael D, Comas, David, Corach, Daniel, D'Amato, Maria E, Davison, Sean, de Knijff, Peter, De Ungria, Maria Corazon A, Decorte, Ronny, Dobosz, Tadeusz, Dupuy, Berit M, Elmrghni, Samir, Gliwiński, Mateusz, Gomes, Sara C, Grol, Laurens, Haas, Cordula, Hanson, Erin, Henke, Jürgen, Henke, Lotte, Herrera-Rodríguez, Fabiola, Hill, Carolyn R, Holmlund, Gunilla, Honda, Katsuya, Immel, Uta-Dorothee, Inokuchi, Shota, Jobling, Mark A, Kaddura, Mahmoud, Kim, Jong S, Kim, Soon H, Kim, Wook, King, Turi E, Klausriegler, Eva, Kling, Daniel, Kovačević, Lejla, Kovatsi, Leda, Krajewski, Paweł, Kravchenko, Sergey, Larmuseau, Maarten H D, Lee, Eun Young, Lessig, Ruediger, Livshits, Ludmila A, Marjanović, Damir, Minarik, Marek, Mizuno, Natsuko, Moreira, Helena, Morling, Niels, Mukherjee, Meeta, Munier, Patrick, Nagaraju, Javaregowda, Neuhuber, Franz, Nie, Shengjie, Nilasitsataporn, Premlaphat, Nishi, Takeki, Oh, Hye H, Olofsson, Jill, Onofri, Valerio, Palo, Jukka U, Pamjav, Horolma, Parson, Walther, Petlach, Michal, Phillips, Christopher, Ploski, Rafal, Prasad, Samayamantri P R, Primorac, Dragan, Purnomo, Gludhug A, Purps, Josephine, Rangel-Villalobos, Hector, Rębała, Krzysztof, Rerkamnuaychoke, Budsaba, Gonzalez, Danel Rey, Robino, Carlo, Roewer, Lutz, Rosa, Alexandra, Sajantila, Antti, Sala, Andrea, Salvador, Jazelyn M, Sanz, Paula, Schmitt, Cornelia, Sharma, Anil K, Silva, Dayse A, Shin, Kyoung-Jin, Sijen, Titia, Sirker, Miriam, Siváková, Daniela, Skaro, Vedrana, Solano-Matamoros, Carlos, Souto, Luis, Stenzl, Vlastimil, Sudoyo, Herawati, Court, Denise Syndercombe, Tagliabracci, Adriano, Taylor, Duncan, Tillmar, Andreas, Tsybovsky, Iosif S, Tyler-Smith, Chris, van der Gaag, Kristiaan J, Vanek, Daniel, Völgyi, Antónia, Ward, Denise, Willemse, Patricia, Yap, Eric P H, Yong, Rita Y Y, Pajnič, Irena Zupanič, Kayser, Manfred
Jazyk: angličtina
Rok vydání: 2014
Zdroj: Ballantyne, K N, Ralf, A, Aboukhalid, R, Achakzai, N M, Anjos, M J, Ayub, Q, Balažic, J, Ballantyne, J, Ballard, D J, Berger, B, Bobillo, C, Bouabdellah, M, Burri, H, Capal, T, Caratti, S, Cárdenas, J, Cartault, F, Carvalho, E F, Carvalho, M, Cheng, B, Coble, M D, Comas, D, Corach, D, D'Amato, M E, Davison, S, de Knijff, P, De Ungria, M C A, Decorte, R, Dobosz, T, Dupuy, B M, Elmrghni, S, Gliwiński, M, Gomes, S C, Grol, L, Haas, C, Hanson, E, Henke, J, Henke, L, Herrera-Rodríguez, F, Hill, C R, Holmlund, G, Honda, K, Immel, U-D, Inokuchi, S, Jobling, M A, Kaddura, M, Kim, J S, Kim, S H, Kim, W, King, T E, Klausriegler, E, Kling, D, Kovačević, L, Kovatsi, L, Krajewski, P, Kravchenko, S, Larmuseau, M H D, Lee, E Y, Lessig, R, Livshits, L A, Marjanović, D, Minarik, M, Mizuno, N, Moreira, H, Morling, N, Mukherjee, M, Munier, P, Nagaraju, J, Neuhuber, F, Nie, S, Nilasitsataporn, P, Nishi, T, Oh, H H, Olofsson, J, Onofri, V, Palo, J U, Pamjav, H, Parson, W, Petlach, M, Phillips, C, Ploski, R, Prasad, S P R, Primorac, D, Purnomo, G A, Purps, J, Rangel-Villalobos, H, Rębała, K, Rerkamnuaychoke, B, Gonzalez, D R, Robino, C, Roewer, L, Rosa, A, Sajantila, A, Sala, A, Salvador, J M, Sanz, P, Schmitt, C, Sharma, A K, Silva, D A, Shin, K-J, Sijen, T, Sirker, M, Siváková, D, Skaro, V, Solano-Matamoros, C, Souto, L, Stenzl, V, Sudoyo, H, Court, D S, Tagliabracci, A, Taylor, D, Tillmar, A, Tsybovsky, I S, Tyler-Smith, C, van der Gaag, K J, Vanek, D, Völgyi, A, Ward, D, Willemse, P, Yap, E P H, Yong, R Y Y, Pajnič, I Z & Kayser, M 2014, ' Towards male individualization with rapidly mutating Y-chromosomal STRs ', Human Mutation, vol. 35, no. 8, pp. 1021-1032 . https://doi.org/10.1002/humu.22599
DOI: 10.1002/humu.22599
Popis: Relevant for various areas of human genetics, Y-chromosomal STRs (Y-STRs) are commonly used for testing close paternal relationships amongst individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly-mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99919-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% non-unique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). AMOVA revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 fathers/son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database.
Databáze: OpenAIRE
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