Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration:a MACUSTAR study report
| Autor: | Saßmannshausen, Marlene, Behning, Charlotte, Isselmann, Ben, Schmid, Matthias, Finger, Robert P., Holz, F. G., Schmitz-Valckenberg, Steffen, Pfau, Maximilian, Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P. G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C. J.F., Böttger, M., Bouchet, C., Brazier, J. E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D. P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Finger, R. P., Fletcher, E., Floyd, H., Francisco, C., Gutfleisch, M., Hogg, R., Hoyng, C. B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y. T.E., Luhmann, U. F.O., Lüning, A., Marques, I. |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Zdroj: | Saßmannshausen, M, Behning, C, Isselmann, B, Schmid, M, Finger, R P, Holz, F G, Schmitz-Valckenberg, S, Pfau, M, Agostini, H, Altay, L, Atia, R, Bandello, F, Basile, P G, Behning, C, Belmouhand, M, Berger, M, Binns, A, Boon, C J F, Böttger, M, Bouchet, C, Brazier, J E, Butt, T, Carapezzi, C, Carlton, J, Carneiro, A, Charil, A, Coimbra, R, Cozzi, M, Crabb, D P, Cunha-Vaz, J, Dahlke, C, de Sisternes, L, Dunbar, H, Finger, R P, Fletcher, E, Floyd, H, Francisco, C, Gutfleisch, M, Hogg, R, Holz, F G, Hoyng, C B, Kilani, A, Krätzschmar, J, Kühlewein, L, Larsen, M, Leal, S, Lechanteur, Y T E, Luhmann, U F O, Lüning, A, Marques, I & MACUSTAR Consortium 2022, ' Relative ellipsoid zone reflectivity and its association with disease severity in age-related macular degeneration : a MACUSTAR study report ', Scientific Reports, vol. 12, 14933 . https://doi.org/10.1038/s41598-022-18875-5 |
| Popis: | Quantification of the relative ellipsoid zone reflectivity (rEZR) might be a structural surrogate parameter for an early disease progression in the context of age-related macular degeneration (AMD). Within the European multicenter, cross-sectional MACUSTAR study, we have devised an automatic approach to determine the mean rEZR [arbitrary units, AU] at two independent visits in SD-OCT volume scans in study participants. Linear mixed-effects models were applied to analyze the association of AMD stage and AMD associated high-risk features including presence of pigmentary abnormalities, reticular pseudodrusen (RPD), volume of the retinal-pigment-epithelial–drusenoid-complex (RPEDC) with the rEZR. Intra-class correlation coefficients (ICC) were determined for rEZR reliability analysis. Within the overall study cohort (301 participants), we could observe decreased rEZR values (coefficient estimate ± standard error) of − 8.05 ± 2.44 AU (p = 0.0011) in the intermediate and of − 22.35 ± 3.28 AU (p < 0.0001) in the late AMD group. RPD presence was significantly associated with the rEZR in iAMD eyes (− 6.49 ± 3.14 AU; p = 0.0403), while there was a good ICC of 0.846 (95% confidence interval: 0.809; 0.876) in the overall study cohort. This study showed an association of rEZR with increasing disease severity and the presence of iAMD high-risk features. Further studies are necessary to evaluate the rEZR’s value as a novel biomarker for AMD and disease progression. |
| Databáze: | OpenAIRE |
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