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Nasibullin Boris A., Gushcha Sergey G., Dekhtyar Yuri N., Volyanska Veronika S., Plakida Alexander. Experimental substantiation of the use of highly mineralized bromine chloride sodium water to correct the functional-metabolic continuum in rats with a model of distress. Journal of Education, Health and Sport. 2023;13(5):124-137. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.13.05.017 https://apcz.umk.pl/JEHS/article/view/44668 https://zenodo.org/record/8066256 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 1, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 1 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe:Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 28.04.2023. Revised: 19.05.2023. Accepted: 31.05.2023. Experimental substantiation of the use of highly mineralized bromine chloride sodium water to correct the functional-metabolic continuum in rats with a model of distress Boris A. Nasibullin1, Sergey G. Gushcha1, Yuri N. Dekhtyar2, Veronika S. Volyanska2, Alexander Plakida1,2 1State Institution «Ukrainian Research Institute of Medical Rehabilitation and Resort Therapy of the Ministry of Health of Ukraine», Odesa, Ukraine 2Odesa National Medical University, Odesa, Ukraine Boris Nasibullin (1): ORCID https://orcid.org/0000-0003-3963-2374; e-mail: gushchasergey11@gmail.com Sergey Gushcha (1): ORCID https://orcid.org/0000-0003-3097-5258; e-mail: gushchasergey11@gmail.com Veronika Volyanska (2): ORCID https://orcid.org/0000-0002-3019-7620; e-mail: mylya1710@gmail.com Alexander Plakida (1, 2): ORCID https://orcid.org/0000-0002-7537-7596; e-mail: aplakida01@gmail.com Abstract The authors studied the state of the functional-metabolic continuum in white rats while modeling psycho-emotional distress. They evaluated the effect of mineral water with a high content of sodium bromine and chlorides, when applied externally, on the state of the body of the test animals in distress. The model of distress in rats is characterized by rearrangements of metabolic reactions: an increase in endogenous intoxication, an increase in the activity of lipid peroxidation against the background of a decrease in the activity of antioxidant defense enzymes, a reduction in the content of creatinine and urea, a decrease in the energy supply of the activity of transmembrane metabolism and alanine aminotransferase (ALAT) and aspartate aminotransferase (AST). Simultaneously with adverse changes in metabolic reactions, signs of dystrophic changes in internal organs are determined. Course external application of mineral water (MW) with a high content of sodium, chlorides and bromine in rats with psycho-emotional distress significantly improves metabolism. The normalization of energy metabolism and balance in the lipid-antioxidant system of indicators of endogenous intoxication and the restoration of the functional state of the liver confirms this. In the internal organs, manifestations of dystrophy disappear. The authors believe that using MW improves the condition of regulatory processes, thereby restoring the functional-metabolic continuum in distressed rats. Keywords: distress; functional-metabolic continuum; bromine chloride sodium mineral water. |
