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Sapuła Klaudia, Gołacki Jakub, Marczak Aleksandra, Hordejuk Michalina, Iwaszko-Sochal Klaudyna. The role of chemokines in liver disease. Journal of Education, Health and Sport. 2022;12(7):493-503. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.07.050 https://apcz.umk.pl/JEHS/article/view/JEHS.2022.12.07.050 https://zenodo.org/record/6833664 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2022; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 22.06.2022. Revised: 22.06.2022. Accepted: 14.07.2022. The role of chemokines in liver disease Klaudia Sapuła, Jakub Gołacki, Aleksandra Marczak, Michalina Hordejuk, Klaudyna Iwaszko-Sochal Klaudia Sapuła klaudiaa.em@gmail.com, https://orcid.org/ 0000-0003-2436-0150 Independent Public Clinical Hospital No. 4 in Lublin Jakub Golacki jakub.golacki@gmail.com, https://orcid.org/0000-0001-8502-3030 Independent Public Clinical Hospital No. 4 in Lublin Aleksandra Marczak aleksandramarczak26@gmail.com, https://orcid.org/0000-0002-3025-5907 Independent Public Clinical Hospital No. 1 in Lublin Michalina Hordejuk michalina.hordejuk@gmail.com, https://orcid.org/0000-0003-2473-1062 Provincial Specialist Hospital in Lublin Klaudyna Iwaszko-Sochal klaudyna.iwaszko92@gmail.com, https://orcid.org/0000-0001-9228-6138 Independent Public Clinical Hospital No. 4 in Lublin Abstract (abstract): Chemokines are involved in many processes, including the normal immune response to infection, as well as pathological processes such as carcinogenesis, autoimmunity and inappropriate inflammatory responses. These processes represent an important aspect in the context of liver disease, its progression and the possibility of inhibiting fibrosis. Chemokines belong to low molecular weight proteins with a wide range of functions affecting cell migration, involving different physiological and pathological processes. Depending on whether they participate in the maintenance of homeostasis during periods of well-being or represent a type of intervention of the organism to its disorders, their secretion by cells is constitutive or induced. This article focuses on the classification, structure and functions of these molecules and their possible involvement in the pathogenesis of liver diseases, as well as the possibilities of therapeutic application of this knowledge. Keywords: chemokines, liver disease, alcoholic liver disease |
