| Popis: |
OŁOWNIA, Aleksandra, ORCZYK, Jakub & KOZIOŁ, Małgorzata. The Influence of Epstein-Barr virus infection on developing multiple sclerosis.Journal of Education, Health and Sport. 2023;22(1):46-55. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.22.01.004 https://apcz.umk.pl/JEHS/article/view/43288 https://zenodo.org/record/7851736 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.03.2023. Revised: 27.03.2023. Accepted: 21.04.2023. Published: 21.04.2023. INFLUENCE OF EPSTEIN-BARR VIRUS INFECTION ON DEVELOPING MULTIPLE SCLEROSIS Aleksandra Ołownia1, Jakub Orczyk1,Małgorzata Kozioł2 1Student Scientific Association at the Chair and Department of Medical Microbiology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland 2Chair of Department of Medical Microbiology, Medical University of Lublin, Poland Corresponding author: Aleksandra Ołownia, Olaolowniax@gmail.com ORCID ID: Aleksandra Ołownia: https://orcid.org/0000-0001-6164-6639 Jakub Orczyk: https://orcid.org/0000-0002-4201-545X Małgorzata Kozioł: https://orcid.org/0000-0001-9079-8594 ABSTRACT Multiple sclerosis (MS) is the most common inflammatory-demyelinating disease. MS leads to the multifocal damage of the central nervous system, which causes the gradual deterioration of sensory, motor and cognitive functions. The etiology of this disease is not fully understood, but genetic and environmental factors (including the EBV infection) are suspected.In this review, we would like to summarize the state of knowledge over the effect of Epstein-Barr virus infection on developing multiple sclerosis. Infectious mononucleosis (IM) which is causedby EBV and MS have similar epidemiology: both diseases mainly affect people at a young age, geographical prevalence is also identical. There are many theories that explain the mechanism of the EBV involvement in the development of MS including: the migration of EBV-infected B cells into the Central Nervous System, the theory of molecular mimicry, the induction of αB-crystallin by EBV in lymphoid cells or cooperation of the EBV and other viruses in the development of MS. Observations by physicians from around the world suggest that EBV infection is a strong factor in the development of multiple sclerosis. Epstein-Barr virus is prevalent in the population. There are a lot of evidences that suggest its involvement in the development of multiple sclerosis. Prevention of EBV infection could potentially reduce the amount of cases of MS. However, more researches are needed to clearly confirm the involvement of EBV in the etiopathogenesis of developing MS. Key words: Demyelinating Disease, Autoimmune Disease, Infectious disease, Herpes viruses, Infectious Mononucleosis, Viral infection |
