| Autor: |
Katerina Nikiforaki, Georgios C. Manikis, Maria Venianaki, Eleftherios Kontopodis, Eleni Lagoudaki, Thomas G. Maris, Kostas Marias, Eelco de Bree, Apostolos Karantanas |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
Tumor necrosis factor alpha (TNF-α) is known to cause selective destruction of tumor neovascularisation. Perfusion changes in tumor microenvironment were studied in a young patient with a high-grade myxoid liposarcoma after isolated limb perfusion with TNF-α and melphalan, using advanced MR imaging. Quantitative and semi-quantitative evaluation of perfusion metrics included ktrans/f/T2* shift and automatic extraction of enhancement patterns. Strong agreement between different methods is consistent with response to therapy, specifically reduced perfusion (mean ktrans shifted from 0.424 to 0.099 mL/g/min, mean f from 33.5 to 7.3%), reduced hypoxia indication (mean T2* increased from 72 to 82 ms) and prevalence of necrotic areas. Abbreviations (TNF-α) : Tumor Necrosis Factor Alpha ILP : Isolated limb perfusion DCE : Dynamic Contrast Enhanced DWI : Diffusion Weighted Imaging IVIM : Intravoxel Incoherent Motion T2*r : T2* Relaxometry BOLD : Blood Oxygen Level-Dependent PK : Pharmacokinetic ktrans : Transendothelial permeability dHb : Deoxyhemoglobin IMVD : Intratumoral Microvessel Density FISH : Fluorescence In situ Hybridization PR : Pattern Recognition |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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