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CIECIERSKI-KOŹLAREK, Hubert, ŻUREK, Urszula, TOŁWIŃSKI, Ignacy, KĘDZIERSKA, Zofia, SZWED, Weronika, ANTKOWIAK, Klaudia, DADAS, Klaudia, ŚWIERCZ, Aleksandra, MAŁACHOWSKA, Dominika and SHVED, Kateryna. The role of exosomes in ischemic stroke. Journal of Education, Health and Sport. 2023;28(1):123-137.eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2023.28.01.010 https://apcz.umk.pl/JEHS/article/view/44828 https://zenodo.org/record/8174045 The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of 17.07.2023 No. 32318. Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences). Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 17.07.2023Lp. 32318. Posiada Unikatowy Identyfikator Czasopisma: 201159. Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu). © The Authors 2023; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 29.06.2023. Revised: 20.07.2023. Accepted: 20.07.2023. Published: 25.07.2023. The role of exosomes in ischemic stroke Hubert Ciecierski-Koźlarek Wojewódzki Szpital Specjalistyczny w Olsztynie, ul. Żołnierska 18, 10-561 Olsztyn, Poland ORCiD: 0009-0009-4062-6888 e-mail: hubertciecierski@icloud.com Urszula Żurek Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland ORCiD: 0009-0008-3482-5381 e-mail: ula.zurek@gmail.com Ignacy Tołwiński Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland ORCiD: 0000-0003-1362-6734 e-mail: ignacyt233@gmail.com Zofia Kędzierska Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland ORCiD: 0000-0002-4181-4719 e-mail: zo.kedzierska@gmail.com Weronika Szwed Wojewódzki Szpital Specjalistyczny w Olsztynie, ul. Żołnierska 18, 10-561 Olsztyn, Poland ORCiD: 0000-0001-9546-7970 e-mail: weronikaszwed1997@gmail.com Klaudia Antkowiak Szpital Średzki Serca Jezusowego z.o.o ul. Żwirki i Wigury 10, 63-000 Środa Wielkopolska, Poland ORCiD: 0009-0008-3421-2200 e-mail: klaudia.antkowiak2021@gmail.com Klaudia Dadas Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland ORCiD: 0009-0007-3352-9807 e-mail: klaudia.w.2703@gmail.com Aleksandra Świercz Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland ORCiD: 0009-0007-1535-1590 e-mail: aleksandra.swiercz1996@gmail.com Dominika Małachowska Warszawski Szpital Południowy, ul. rtm. Witolda Pileckiego 99, 02-781 Warszawa, Poland ORCiD: 0009-0008-6305-7959 e-mail: dominika1.malachowska@gmail.com Kateryna Shved Wielospecjalistyczny Szpital Miejski im. Józefa Strusia, ul. Szwajcarska 3, 61-285 Poznań, Poland ORCiD: 0009-0002-3773-7025 e-mail: katey.shved@gmail.com Abstract Introduction and purpose: Ischemic stroke is one of the leading causes of death and disability worldwide. There is an urgent need to develop new treatments and diagnosis. The aim of this review is to gather current knowledge on the potential use of exosomes in the diagnosis and treatment of ischemic stroke. This review was based on available data collected in the Pub Med database and Google Scholar web search engine, using the key words: „Exosomes”, „ischemic stroke” Description of the state of knowledge: Currently, thanks to the development of knowledge about molecular processes, many studies are conducted on drugs that could limit neurodegenerative processes and support repair processes. Many of the drugs that could be used in treatment show poor penetration through the blood-brain barrier. In studies, exosomes show good penetration through the blood-brain barrier, limit neurodegenerative processes and show neuroregenerative effects. Exosomes are characterized by low immunogenicity and toxicity, and the proteins contained in them are involved in neurogenesis, anti-apoptotic processes and synaptic transmission. In addition, studies have shown exosomes inhibit autophagocytosis and reduce neuronal damage. Summary: Studies performed on animal models have shown the effectiveness of exosomes in the diagnosis and treatment of ischemic stroke. Further studies are needed to determine the efficacy and safety profile of exosomes in humans. Keywords:Exosomes; ischemic stroke; ischemia; microRNA; neurodegenerative processes; neurorestoration |
