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Kovalchuk Khrystyna. New risk factors in progression of age-related macular degeneration. Journal of Education, Health and Sport. 2020;10(10):90-101. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.10.009 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.10.009 https://zenodo.org/record/4156249 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 12.10.2020. Revised: 16.10.2020. Accepted: 29.10.2020. New risk factors in progression of age-related macular degeneration Khrystyna Kovalchuk Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine PhD-student, Ophthalmology Department Abstract Background. Allot of studies investigate the etiology and pathogenesis of age-related macular degeneration (AMD). The exudative form of AMD is the leading cause of irreversible blindness in the elderly. At the same time neurosensory retina detachment in AMD has high level of prevalence and severity of comlications but little attention has been paid to explaying the risk factors of retina edema and the possibility of their role on the interstitial fluid accumulation. The investigation of patterns for predicting the risk of retinal detachment is still cosiderable, as this is important for patients selection with high risk of developing retinal detachment of AMD and effective preventive treatment. Purpose: To investigate new risk factors for the progression of age-related macular degeneration. Materials and methods. The prospective study included 37 patients (67 eyes) with the exudative form of AMD (Category 4 according to the AREDS). 21 (56.8%) patients had exudative detachment of neurosensory retina. The ophthalmologic examination included anamnesis, visometry, tonometry, biomicroscopy, ophthalmoscopy and optical coherence tomography. ATP, ADP, adenosine, platelet-activating factor (PAF), adrenaline and isadrin were used to study the functional activity of platelet receptors. The evaluation of platelet aggregation was carried out by a turbidimetric method. Methods of pair correlation analysis and multiple linear regression models were used to analyse the relationship between the values of individual agonists the retinal detachment. Results. After analysis of nine items, three of which were found to be significantly associated with serous detachment of neurosensory retina, including the activity of PAF receptors, adenosine A2A receptors and α2-adrenoreceptors. The prognosis of the cases of this complication in the general cohort of patients with exudative AMD turned out to be positive in 87.5%. Conclusions. Correlation between the development of exudative detachment of neurosensory retina and the functional state of Pl can be used in the selection for preventive treatment of patients with retinal detachment in AMD. Key words: age-related macular degeneration; platelet’s receptors; model of prediction of complications. |
