Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity
| Autor: | Couto Alves, A, Valcarcel, B, Mäkinen, V-P, Morin-Papunen, L, Sebert, S, Kangas, A J, Soininen, P, Das, S, De Iorio, M, Coin, L, Ala-Korpela, M, Järvelin, M-R |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Obesity Abdominal/epidemiology endocrine system diseases Insulin/metabolism Waist Circumference/physiology Finland/epidemiology nutritional and metabolic diseases Polycystic Ovary Syndrome/epidemiology Testosterone/metabolism Evaluation Studies as Topic Hyperandrogenism/epidemiology Humans Metabolomics Dyslipidemias/epidemiology Female Insulin Resistance/physiology |
| Zdroj: | Couto Alves, A, Valcarcel, B, Mäkinen, V-P, Morin-Papunen, L, Sebert, S, Kangas, A J, Soininen, P, Das, S, De Iorio, M, Coin, L, Ala-Korpela, M & Järvelin, M-R 2017, ' Metabolic profiling of polycystic ovary syndrome reveals interactions with abdominal obesity ', International Journal of Obesity, vol. 41, no. 9, pp. 1331-1340 . https://doi.org/10.1038/ijo.2017.126 |
| DOI: | 10.1038/ijo.2017.126 |
| Popis: | BACKGROUND: Polycystic ovary syndrome (PCOS) is a common reproductive disorder associated with metabolic disturbances including obesity, insulin resistance and diabetes mellitus. Here we investigate whether changes in the metabolic profile of PCOS women are driven by increased tendency to obesity or are specific features of PCOS related to increased testosterone levels.DESIGN AND METHODS: We conducted an NMR metabolomics association study of PCOS cases (n=145) and controls (n=687) nested in a population-based birth cohort (n=3127). Subjects were 31 years old at examination. The main analyses were adjusted for waist circumference (WC) as a proxy measure of central obesity. Subsequently, metabolite concentrations were compared between cases and controls within pre-defined WC strata. In each stratum, additional metabolomics association analyses with testosterone levels were conducted separately among cases and controls.RESULTS: Overall, women with PCOS showed more adverse metabolite profiles than the controls. Four lipid fractions in different subclasses of very low density lipoprotein (VLDL) were associated with PCOS, after adjusting for WC and correction for multiple testing (PCONCLUSIONS: Our findings show that both abdominal obesity and hyperandrogenism contribute to the dyslipidaemia and other metabolic traits of PCOS which all may negatively contribute to the long-term health of women with PCOS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|