| Přispěvatelé: |
[Martinez-Poveda, Beatriz] Univ Malaga, Dept Mol Biol & Biochem, Fac Sci, Andalucia Tech, E-29071 Malaga, Spain, [Quesada, Ana R.] Univ Malaga, Dept Mol Biol & Biochem, Fac Sci, Andalucia Tech, E-29071 Malaga, Spain, [Angel Medina, Miguel] Univ Malaga, Dept Mol Biol & Biochem, Fac Sci, Andalucia Tech, E-29071 Malaga, Spain, [Martinez-Poveda, Beatriz] IBIMA, E-29071 Malaga, Spain, [Quesada, Ana R.] IBIMA, E-29071 Malaga, Spain, [Angel Medina, Miguel] IBIMA, E-29071 Malaga, Spain, [Quesada, Ana R.] Unidad 741 CIBER Enfermedades Raras, E-29071 Malaga, Spain, [Angel Medina, Miguel] Unidad 741 CIBER Enfermedades Raras, E-29071 Malaga, Spain, MINECO, FEDER, Andalusian Government |
| Popis: |
Marine sponges represent a vast source of metabolites with very interesting potential biomedical applications. Puupehenones are sesquiterpene quinones isolated from sponges of the orders Verongida and Dictyoceratida. This family of chemical compounds is composed of a high number of metabolites, including puupehenone, the most characteristic compound of the family. Chemical synthesis of puupehenone has been reached by different routes, and the special chemical reactivity of this molecule has allowed the synthesis of many puupehenone-derived compounds. The biological activities of puupehenones are very diverse, including antiangiogenic, antitumoral, antioxidant, antimicrobial, immunomodulatory and antiatherosclerotic effects. Despite the very important roles described for puupehenones concerning different pathologies, the exact mechanism of action of these compounds and the putative therapeutic effects in vivo remain to be elucidated. This review offers an updated and global view about the biology of puupehenones and their therapeutic possibilities in human diseases such as cancer. |
