Coenzyme Q10 and Cardiovascular Diseases
| Autor: | Gutierrez-Mariscal, Francisco M., de la Cruz-Ares, Silvia, Torres-Peña, Jose D., Alcalá-Diaz, Juan F., Yubero-Serrano, Elena M., López-Miranda, José |
|---|---|
| Přispěvatelé: | [Gutierrez-Mariscal,FM, de la Cruz-Ares,S, Torres-Peña,JD, Alcalá-Diaz,JF, Yubero-Serrano,EM, López-Miranda,J] Lipids and Atherosclerosis Unit, Unidad de Gestión Clínica de Medicina Interna, Maimonides Institute for Biomedical Research in Córdoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain. [Gutierrez-Mariscal,FM, López-Miranda,J] CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain., Elena M Yubero-Serrano was the recipient of the Nicolas Monardes Program from the 'Servicio Andaluz de Salud, Junta de Andalucia', Spain (C1-0005-2019). |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Coenzimas
Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antimetabolites::Hypolipidemic Agents::Anticholesteremic Agents::Hydroxymethylglutaryl-CoA Reductase Inhibitors [Medical Subject Headings] Ubiquinone Ubiquinona Chemicals and Drugs::Lipids::Lipoproteins [Medical Subject Headings] Lipoproteínas Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings] Phenomena and Processes::Metabolic Phenomena::Pharmacokinetics::Biological Availability [Medical Subject Headings] Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants [Medical Subject Headings] Cardiovascular diseases Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Hemodynamics::Blood Pressure [Medical Subject Headings] Factores de riesgo de enfermedades cardíacas Coenzyme Q10 Ubiquinol Enfermedades cardiovasculares Diseases::Cardiovascular Diseases [Medical Subject Headings] Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism::Oxidation-Reduction::Electron Transport [Medical Subject Headings] Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Mitochondria [Medical Subject Headings] |
| Popis: | Coenzyme Q10 (CoQ10), which plays a key role in the electron transport chain by providing an adequate, efficient supply of energy, has another relevant function as an antioxidant, acting in mitochondria, other cell compartments, and plasma lipoproteins. CoQ10 deficiency is present in chronic and age-related diseases. In particular, in cardiovascular diseases (CVDs), there is a reduced bioavailability of CoQ10 since statins, one of the most common lipid-lowering drugs, inhibit the common pathway shared by CoQ10 endogenous biosynthesis and cholesterol biosynthesis. Different clinical trials have analyzed the effect of CoQ10 supplementation as a treatment to ameliorate these deficiencies in the context of CVDs. In this review, we focus on recent advances in CoQ10 supplementation and the clinical implications in the reduction of cardiovascular risk factors (such as lipid and lipoprotein levels, blood pressure, or endothelial function) as well as in a therapeutic approach for the reduction of the clinical complications of CVD. Yes |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|