Breast and Gut Microbiota Action Mechanisms in Breast Cancer Pathogenesis and Treatment
| Autor: | Laborda-Illanes, Aurora, Sanchez-Alcoholado, Lidia, Dominguez-Recio, María Emilia, Jimenez-Rodriguez, Begoña, Lavado, Rocío, Comino-Méndez, Iñaki, Alba, Emilio, Queipo-Ortuño, María Isabel |
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| Přispěvatelé: | [Laborda-Illanes,A, Sanchez-Alcoholado,L, Dominguez-Recio,ME, Jimenez-Rodriguez,B, Lavado,R, Comino-Méndez,I, Alba,E, Queipo-Ortuño,MI] Unidad de Gestión Clínica Intercentros de Oncología Médica, Hospitales Universitarios Regional y Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA)-CIMES-UMA, Málaga, Spain. [Laborda-Illanes,A, Sanchez-Alcoholado,L] Facultad de Medicina, Universidad de Málaga, Málaga, Spain., This work was supported in part by PE-0106-2019 from the Consejería de Salud de la Junta de Andalucía, C19047-2018 from Fundación Unicaja and UMA18-FEDERJA-042 from UMA-FEDER. Maria Isabel Queipo-Ortuño is recipient of a 'Miguel Servet Type II' program (CPI13/00003) from ISCIII, co-funded by the Fondo Europeo de Desarrollo Regional-FEDER, Madrid, Spain and also belongs to the regional 'Nicolas Monardes' research program of the Consejería de Salud (C-0030-2018, Junta de Andalucía, Spain. Aurora Laborda-Illanes was recipient of a predoctoral grant PFIS-ISCIII (FI19-00112) co-funded by the Fondo Europeo de Desarrollo Regional-FEDER, Madrid, Spain. Lidia Sanchez-Alcoholado was recipient of a predoctoral grant (PE-0106-2019) from the Consejería de Salud y Familia (co-funded by the Fondo Europeo de Desarrollo Regional-FEDER, Andalucia, Spain). |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Prebióticos
Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors [Medical Subject Headings] Breast cancer Inmunidad Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Sexual Development::Climacteric::Menopause::Postmenopause [Medical Subject Headings] Estrobolome Immune responds Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms [Medical Subject Headings] Inflammation Inflamación Microbiota Probiotics Anticancer therapy Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents [Medical Subject Headings] Probióticos Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis Genetic [Medical Subject Headings] Phenomena and Processes::Immune System Phenomena::Immunity [Medical Subject Headings] Antineoplásicos Prebiotics Phenomena and Processes::Microbiological Phenomena::Microbiota [Medical Subject Headings] Check Tags::Female [Medical Subject Headings] Neoplasias de la mama Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings] Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Dysbiosis [Medical Subject Headings] Epigenetic modulation Chemicals and Drugs::Carbohydrates::Polysaccharides::Polysaccharides Bacterial::Prebiotics [Medical Subject Headings] Epigénesis genética Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Inflammation [Medical Subject Headings] |
| Popis: | In breast cancer (BC) the employment of sequencing technologies for metagenomic analyses has allowed not only the description of the overall metagenomic landscape but also the specific microbial changes and their functional implications. Most of the available data suggest that BC is related to bacterial dysbiosis in both the gut microenvironment and breast tissue. It is hypothesized that changes in the composition and functions of several breast and gut bacterial taxa may contribute to BC development and progression through several pathways. One of the most prominent roles of gut microbiota is the regulation of steroid-hormone metabolism, such as estrogens, a component playing an important role as risk factor in BC development, especially in postmenopausal women. On the other hand, breast and gut resident microbiota are the link in the reciprocal interactions between cancer cells and their local environment, since microbiota are capable of modulating mucosal and systemic immune responses. Several in vivo and in vitro studies show remarkable evidence that diet, probiotics and prebiotics could exert important anticarcinogenic effects in BC. Moreover, gut microbiota have an important role in the metabolism of chemotherapeutic drugs and in the activity of immunogenic chemotherapies since they are a potential dominant mediator in the response to cancer therapy. Then, the microbiome impact in BC is multi-factorial, and the gut and breast tissue bacteria population could be important in regulating the local immune system, in tumor formation and progression and in therapy response and/or resistance. Yes |
| Databáze: | OpenAIRE |
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