Primary and Acquired Resistance to Immunotherapy in Lung Cancer: Unveiling the Mechanisms Underlying of Immune Checkpoint Blockade Therapy
| Autor: | Boyero, Laura, Sánchez-Gastaldo, Amparo, Alonso, Miriam, Noguera-Uclés, José Francisco, Molina-Pinelo, Sonia, Bernabé-Caro, Reyes |
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| Přispěvatelé: | [Boyero,L, Noguera-Uclés,JF, Molina-Pinelo,S, Bernabé-Caro,R] Institute of Biomedicine of Seville (IBiS) (HUVR, CSIC, Universidad de Sevilla), Seville, Spain. [Sánchez-Gastaldo,A, Alonso,M, Bernabé-Caro,R] Medical Oncology Department, Hospital Universitario Virgen del Rocio, Seville, Spain. [Molina-Pinelo,S] Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., S.M.-P. is funded by the Ministry of Health and Social Welfare of Junta de Andalucía (Nicolas Monardes Program C-0040-201, and OH-0022-2018) and ISCIII (PI17/00033 and PI20/01109) (co-funded by the European Regional Development Fund) 'A way to make Europe'. L.B. is funded by the Ministry of Health and Social Welfare of Junta de Andalucía (RH-0051-2020). |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Diseases::Pathological Conditions
Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence [Medical Subject Headings] Neoplasias pulmonares Carcinoma pulmonar de células pequeñas Resistance mechanisms NSCLC Carcinoma de pulmón de células no pequeñas Diseases::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms [Medical Subject Headings] PD-1/PD-L1 Antígeno B7-H1 Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Immune checkpoint inhibitors Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy [Medical Subject Headings] Inmunoterapia Anatomy::Hemic and Immune Systems::Immune System::Leukocytes::Leukocytes Mononuclear::Lymphocytes::T-Lymphocytes [Medical Subject Headings] Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction [Medical Subject Headings] Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis Genetic [Medical Subject Headings] SCLC Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment [Medical Subject Headings] Receptor de muerte celular programada 1 Inhibidores de puntos de control inmunológico Phenomena and Processes::Microbiological Phenomena::Microbiota [Medical Subject Headings] Anticuerpos monoclonales Anthropology Education Sociology and Social Phenomena::Social Sciences::Quality of Life [Medical Subject Headings] Monoclonal antibodies Immunotherapy Lung cancer |
| Popis: | After several decades without maintained responses or long-term survival of patients with lung cancer, novel therapies have emerged as a hopeful milestone in this research field. The appearance of immunotherapy, especially immune checkpoint inhibitors, has improved both the overall survival and quality of life of patients, many of whom are diagnosed late when classical treatments are ineffective. Despite these unprecedented results, a high percentage of patients do not respond initially to treatment or relapse after a period of response. This is due to resistance mechanisms, which require understanding in order to prevent them and develop strategies to overcome them and increase the number of patients who can benefit from immunotherapy. This review highlights the current knowledge of the mechanisms and their involvement in resistance to immunotherapy in lung cancer, such as aberrations in tumor neoantigen burden, effector T-cell infiltration in the tumor microenvironment (TME), epigenetic modulation, the transcriptional signature, signaling pathways, T-cell exhaustion, and the microbiome. Further research dissecting intratumor and host heterogeneity is necessary to provide answers regarding the immunotherapy response and develop more effective treatments for lung cancer. Yes |
| Databáze: | OpenAIRE |
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