Nanomedicine to Overcome Multidrug Resistance Mechanisms in Colon and Pancreatic Cancer: Recent Progress
| Autor: | Ortíz, Raúl, Quiñonero, Francisco, García-Pinel, Beatriz, Fuel, Marco, Mesas, Cristina, Cabeza, Laura, Melguizo, Consolación, Prados, Jose |
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| Přispěvatelé: | [Ortíz,R, Quiñonero,F, García-Pinel,B, Fuel,M, Mesas,C, Cabeza,L, Melguizo,C, Prados,J] Institute of Biopathology and Regenerative Medicine (IBIMER), Center of Biomedical Research (CIBM), University of Granada, Granada, Spain. [Ortíz,R, Prados,J] Department of Anatomy and Embriology, Faculty of Medicine, University of Granada, Granada, Spain. [Ortíz,R, Prados,J] Instituto Biosanitario de Granada (ibs.GRANADA), Granada, Spain., This work was funded by the Consejería de Salud de la Junta de Andalucía (projects PI-0102-2017 and P18-HO-3882) and by the CTS-107 Group. This research was partially supported by a grant from the Instituto de Salud Carlos III (ISCIII) (Project PI19/01478) (FEDER). |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Repair [Medical Subject Headings]
Anatomy::Cells::Stem Cells::Neoplastic Stem Cells [Medical Subject Headings] Anatomy::Digestive System::Gastrointestinal Tract::Intestines::Intestine Large::Colon [Medical Subject Headings] Resistencia a medicamentos Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome::Treatment Failure [Medical Subject Headings] PARP Microambiente tumoral Disciplines and Occupations::Natural Science Disciplines::Nanotechnology::Nanomedicine [Medical Subject Headings] Neoplasias del colon Chemicals and Drugs::Macromolecular Substances::Micelles [Medical Subject Headings] Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Drug Resistance [Medical Subject Headings] Technology and Food and Beverages::Technology Industry and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles [Medical Subject Headings] miRNA MicroARNs Neoplasias pancreáticas Poli(ADP-Ribosa) polimerasas Pancreatic cancer Colon cancer Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Pancreatic Neoplasms [Medical Subject Headings] Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Antisense Elements (Genetics)::RNA Antisense::MicroRNAs [Medical Subject Headings] Nanomedicine Tumor microenvironment Drug resistance Nanomedicina Chemicals and Drugs::Macromolecular Substances::Polymers::Dendrimers [Medical Subject Headings] Chemicals and Drugs::Biomedical and Dental Materials::Membranes Artificial::Liposomes [Medical Subject Headings] |
| Popis: | The development of drug resistance is one of the main causes of cancer treatment failure. This phenomenon occurs very frequently in different types of cancer, including colon and pancreatic cancers. However, the underlying molecular mechanisms are not fully understood. In recent years, nanomedicine has improved the delivery and efficacy of drugs, and has decreased their side effects. In addition, it has allowed to design drugs capable of avoiding certain resistance mechanisms of tumors. In this article, we review the main resistance mechanisms in colon and pancreatic cancers, along with the most relevant strategies offered by nanodrugs to overcome this obstacle. These strategies include the inhibition of efflux pumps, the use of specific targets, the development of nanomedicines affecting the environment of cancer-specific tissues, the modulation of DNA repair mechanisms or RNA (miRNA), and specific approaches to damage cancer stem cells, among others. This review aims to illustrate how advanced nanoformulations, including polymeric conjugates, micelles, dendrimers, liposomes, metallic and carbon-based nanoparticles, are allowing to overcome one of the main limitations in the treatment of colon and pancreatic cancers. The future development of nanomedicine opens new horizons for cancer treatment. Yes |
| Databáze: | OpenAIRE |
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