Role of Mesenchymal Stromal Cells as Therapeutic Agents: Potential Mechanisms of Action and Implications in Their Clinical Use
| Autor: | Jimenez-Puerta, Gonzalo José, Marchal, Juan Antonio, López-Ruiz, Elena, Gálvez-Martín, Patricia |
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| Přispěvatelé: | [Jimenez-Puerta,GJ, Marchal,JA, López-Ruiz.E] Biosanitary Research Institute of Granada (ibs.GRANADA), University Hospitals of Granada-University of Granada, Granada, Spain. [Marchal,JA, López-Ruiz.E] Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada, Granada, Spain. [Marchal,JA] Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain. [Marchal,JA, López-Ruiz.E] Excellence Research Unit 'Modeling Nature' (MNat), University of Granada, Granada, Spain. [López-Ruiz.E] Department of Health Sciences, University of Jaén, Jaén, Spain. [Gálvez-Martín,P] Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain. [Gálvez-Martín,P] R&D Human Health, Bioibérica S.A.U., Barcelona, Spain., This work was supported by the Fundación Mutua Madrileña (project FMM-AP17196-2019) and by the Ministerio de Economía, Industria y Competitividad (FEDER funds, project RTC-2016-5451-1). |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Homing
Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics [Medical Subject Headings] Mesenchymal stromal cells Anatomy::Hemic and Immune Systems::Immune System [Medical Subject Headings] Anatomy::Cells [Medical Subject Headings] Células madre mesenquimatosas Mechanism of action Immunomodulation Tejidos Células Anatomy::Cells::Stem Cells::Multipotent Stem Cells::Mesenchymal Stromal Cells [Medical Subject Headings] Anatomy::Tissues [Medical Subject Headings] Movimiento celular Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy [Medical Subject Headings] |
| Popis: | Due to the great therapeutic interest that involves the translation of mesenchymal stromal cells (MSCs) into clinical practice, they have been widely studied as innovative drugs, in order to treat multiple pathologies. MSC-based cell therapy involves the administration of MSCs either locally or systemically into the receptor body where they can traffic and migrate towards the affected tissue and participate in the process of healing. The therapeutic effects of MSCs compromise of different mechanisms such as the functional integration of differentiated MSCs into diseased host tissue after transplantation, their paracrine support, and their impact on the regulation of both the innate and the acquired immune system. Here, we establish and provide recent advances about the principal mechanisms of action through which MSCs can perform their activity and effect as a therapeutic tool. The purpose of this review is to examine and discuss the MSCs capacity of migration, their paracrine effect, as well as MSC-mediated modifications on immune cell responses. Yes |
| Databáze: | OpenAIRE |
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