Insights into Growth Factors in Liver Carcinogenesis and Regeneration: An Ongoing Debate on Minimizing Cancer Recurrence after Liver Resection
| Autor: | Álvarez-Mercado, Ana I., Caballeria-Casals, Albert, Rojano-Alfonso, Carlos, Chávez-Reyes, Jesús, Micó-Carnero, Marc, Sanchez-Gonzalez, Alfredo, Casillas-Ramírez, Araní, Gracia-Sancho, Jordi, Peralta, Carmen |
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| Přispěvatelé: | [Álvarez-Mercado,AI] Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain. [Álvarez-Mercado,AI] Institute of Nutrition and Food Technology, Biomedical Research Center, University of Granada, Armilla, Spain. [Álvarez-Mercado,AI] Instituto de Investigación Biosanitaria ibs.GRANADA, Complejo Hospitalario Universitario de Granada, Granada, Spain. [Caballeria-Casals,A, Rojano-Alfonso,C, Micó-Carnero,M, Peralta,C] Hepatic Ischemia-Reperfusion Injury Department, Institut de Recerca Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [Chávez-Reyes,J, Casillas-Ramírez,A] Facultad de Medicina e Ingeniería en Sistemas Computacionales Matamoros, Universidad Autónoma de Tamaulipas, Matamoros, Mexico. [Sanchez-Gonzalez,A, Casillas-Ramírez,A] Teaching and Research Department, Hospital Regional de Alta Especialidad de Ciudad Victoria 'Bicentenario 2010', Ciudad Victoria, Mexico. [Gracia-Sancho,J] Liver Vascular Biology Research Group, Barcelona Hepatic Hemodynamic Laboratory, IDIBAPS Biomedical Research Institute, CIBEREHD, Barcelona, Spain. [Gracia-Sancho,J] Barcelona Hepatic Hemodynamic Laboratory, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain., This research was funded by the Ministerio de Ciencia, Innovación y Universidades (Project Grant RTI2018-095114-B-I00) Madrid, Spain, European Union (Fondos FEDER, 'una manera de hacer Europa'), CERCA Program/Generalitat de Catalunya, the Secretaria d’ Universitats I Recerca del Departament d’ Economia I Coneixement (Project Grant 2017_SGR_551) Barcelona, Spain, by the COST action Programs CA17103 (DARTER), CA17112 (PRO-EURO-DILI-NET), CA17121 (COMULIS) and CA17126 (TUMIEE), and by the Consejo Nacional de Ciencia y Tecnología (CONACYT), Fondo Sectorial de Investigación para la Educación (Project grant 257743), México. Marc Micó-Carnero is the recipient of a fellowship from FCT (Fundació Catalana de Trasplantament), Spain. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Hepatocyte growth factor
Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms::Carcinoma Hepatocellular [Medical Subject Headings] Phenomena and Processes::Digestive System and Oral Physiological Phenomena::Digestive System Physiological Phenomena::Digestive System Processes::Liver Regeneration [Medical Subject Headings] Liver resection Péptidos y proteínas de señalización intercelular Regeneración Factor de crecimiento de hepatocito Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms [Medical Subject Headings] Epidermal growth factor Chemicals and Drugs::Amino Acids Peptides and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Hepatocyte Growth Factor [Medical Subject Headings] Diseases::Neoplasms::Neoplastic Processes::Carcinogenesis [Medical Subject Headings] Factor de crecimiento epidérmico Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] Insulin-like growth factor-1 Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Digestive System Surgical Procedures::Hepatectomy [Medical Subject Headings] Regeneration Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Epidermal Growth Factor [Medical Subject Headings] Growth factors Hepatectomía Factor I del crecimiento similar a la insulina Liver cancer Carcinoma hepatocelular Chemicals and Drugs::Amino Acids Peptides and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Somatomedins [Medical Subject Headings] |
| Popis: | Hepatocellular carcinoma has become a leading cause of cancer-associated mortality throughout the world, and is of great concern. Currently used chemotherapeutic drugs in the treatment of hepatocellular carcinoma lead to severe side effects, thus underscoring the need for further research to develop novel and safer therapies. Liver resection in cancer patients is routinely performed. After partial resection, liver regeneration is a perfectly calibrated response apparently sensed by the body's required liver function. This process hinges on the effect of several growth factors, among other molecules. However, dysregulation of growth factor signals also leads to growth signaling autonomy and tumor progression, so control of growth factor expression may prevent tumor progression. This review describes the role of some of the main growth factors whose dysregulation promotes liver tumor progression, and are also key in regenerating the remaining liver following resection. We herein summarize and discuss studies focused on partial hepatectomy and liver carcinogenesis, referring to hepatocyte growth factor, insulin-like growth factor, and epidermal growth factor, as well as their suitability as targets in the treatment of hepatocellular carcinoma. Finally, and given that drugs remain one of the mainstay treatment options in liver carcinogenesis, we have reviewed the current pharmacological approaches approved for clinical use or research targeting these factors. Yes |
| Databáze: | OpenAIRE |
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