OXA-48 Carbapenemase-Producing Enterobacterales in Spanish Hospitals: An Updated Comprehensive Review on a Rising Antimicrobial Resistance
| Autor: | Rivera-Izquierdo, Mario, Láinez-Ramos-Bossini, Antonio Jesús, Rivera-Izquierdo, Carlos, López-Gómez, Jairo, Fernández-Martínez, Nicolás Francisco, Redruello-Guerrero, Pablo, Martín-delosReyes, Luis Miguel, Martínez-Ruiz, Virginia, Moreno-Roldán, Elena, Jiménez-Mejías, Eladio |
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| Přispěvatelé: | [Rivera-Izquierdo,M, Rivera-Izquierdo,C, Martín-delosReyes,LM, Martínez-Ruiz,V, Moreno-Roldán,E, Jiménez-Mejías,E] Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain. [Rivera-Izquierdo,M] Service of Preventive Medicine and Public Health, Hospital Clínico San Cecilio, Granada, Spain. [Rivera-Izquierdo,M, Jiménez-Mejías,E] Biosanitary Institute of Granada, ibs. Granada, Granada.Spain. [Láinez-Ramos-Bossini,AJ] Department of Radiology, University of Granada, Granada, Spain. [Rivera-Izquierdo,C] Service of Ginecology and Obstetrics, Hospital Universitario Virgen de las Nieves, Granada, Spain. [López-Gómez,J] Service of Internal Medicine, San Cecilio University Hospital, Granada, Spain. [Fernández-Martínez,NF] Department of Preventive Medicine and Public Health, Reina Sofía University Hospital, Córdoba, Spain. [Fernández-Martínez,NF] Maimonides Biomedical Research Institute of Córdoba (IMIBIC), Córdoba, Spain. [Redruello-Guerrero,P] School of Medicine, University of Granada, Granada, Spain. [Rivera-Izquierdo,M] CIBER of Epidemiology and Public Health of Spain (CIBERESP), Madrid, Spain. [Rivera-Izquierdo,M] Teaching and Research in Family Medicine SEMERGEN-UGR, University of Granada, Granada, Spain., This work was supported by the Chair of Teaching and Research in Family Medicine SEMERGEN-UGR. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Antibiotic stewardship
Phenomena and Processes::Genetic Phenomena::Genetic Structures::Plasmids [Medical Subject Headings] Enterobacteria Health Care::Environment and Public Health::Public Health::Disease Outbreaks [Medical Subject Headings] España Outbreak biochemical phenomena metabolism and nutrition Disciplines and Occupations::Health Occupations::Medicine::Public Health [Medical Subject Headings] Brotes de enfermedades Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Cephalosporins [Medical Subject Headings] Carbapenémicos Carbapenemase Spain Phenomena and Processes::Microbiological Phenomena::Bacterial Physiological Phenomena::Drug Resistance Bacterial [Medical Subject Headings] Carbapenem Multiresistant Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Carbapenems [Medical Subject Headings] OXA-48 Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents [Medical Subject Headings] |
| Popis: | Carbapenemase-producing Enterobacterales (CPE) are significant contributors to the global public health threat of antimicrobial resistance. OXA-48-like enzymes and their variants are unique carbapenemases with low or null hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins. CPEs have been classified by the WHO as high-priority pathogens given their association with morbidity and mortality and the scarce number of effective antibiotic treatments. In Spain, the frequency of OXA-48 CPE outbreaks is higher than in other European countries, representing the major resistance mechanism of CPEs. Horizontal transfer of plasmids and poor effective antibiotic treatment are additional threats to the correct prevention and control of these hospital outbreaks. One of the most important risk factors is antibiotic pressure, specifically carbapenem overuse. We explored the use of these antibiotics in Spain and analyzed the frequency, characteristics and prevention of CPE outbreaks. Future antibiotic stewardship programs along with specific preventive measures in hospitalized patients must be reinforced and updated in Spain. Yes |
| Databáze: | OpenAIRE |
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